曲尼司特通过TGF-β/Smad信号通路对糖尿病大鼠心肌纤维化的影响 - Suppr

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超能文献

Effect of tranilast on myocardial fibrosis in diabetes rats through TGF-β/Smad pathway.

作者信息

Li Xiao, Liu Jie, Shang Xingfu

机构信息

Department of Cardiology, the Third People's Hospital of Qingdao, Qingdao, China -

Department of Cardiology, the Third People's Hospital of Qingdao, Qingdao, China.

出版信息

Minerva Med. 2021 Feb;112(1):153-154. doi: 10.23736/S0026-4806.19.06178-0. Epub 2019 Jul 9.

DOI:10.23736/S0026-4806.19.06178-0

PMID:31295986

Abstract

摘要

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Effect of tranilast on myocardial fibrosis in diabetes rats through TGF-β/Smad pathway.曲尼司特通过TGF-β/Smad信号通路对糖尿病大鼠心肌纤维化的影响

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Tranilast reduces cardiomyocyte injury induced by ischemia‑reperfusion via Nrf2/HO‑1/NF‑κB signaling.曲尼司特通过Nrf2/HO-1/NF-κB信号通路减轻缺血再灌注诱导的心肌细胞损伤。

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NLRP3 Inhibitor Tranilast Attenuates Gestational Diabetes Mellitus in a Genetic Mouse Model.NLRP3 抑制剂曲尼司特可减轻遗传型糖尿病小鼠的妊娠期糖尿病。

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