Minota S, Koketsu K
Jpn J Physiol. 1978;28(6):799-806. doi: 10.2170/jjphysiol.28.799.
In a certain group (type 2 cells) of bullfrog sympathetic ganglion cells, an action potential exhibiting a triphasic after-potential was produced when the cells were activated by direct intracellular stimulation. This triphasic after-potential consisted of two different potential components, namely, a depolarizing response (DR) and an after-hyperpolarization. The amplitude of DR was increased by increasing the interval between stimuli. Large DRs exceeded the threshold of the cell membrane and produced repetitive firings of spike potentials. The DR was selectively depressed and eventually eliminated in a low-Ca solution. Eserine (10(-5) M) reversibly increased both the amplitude and duration of the DR, and d-tubocurarine reversibly depressed it. These results indicate that the DR of type 2 cells is the EPSP mediated by the nicotinic action of acetylcholine released from preganglionic nerve terminals. Preganglionic nerve fibers innervating type 2 cells are activated through some kind of recurrent pathway formed between them. Recurrent activation of type 2 cells seems to be thus induced when the cells are activated by direct intracellular stimulation.
在牛蛙交感神经节细胞的某一组（2型细胞）中，当通过直接细胞内刺激激活这些细胞时，会产生具有三相后电位的动作电位。这种三相后电位由两个不同的电位成分组成，即去极化反应（DR）和后超极化。DR的幅度通过增加刺激间隔而增大。大的DR超过细胞膜阈值并产生重复的锋电位发放。DR在低钙溶液中被选择性抑制并最终消除。毒扁豆碱（10⁻⁵ M）可逆地增加DR的幅度和持续时间，而筒箭毒碱则可逆地抑制它。这些结果表明，2型细胞的DR是由节前神经末梢释放的乙酰胆碱的烟碱样作用介导的兴奋性突触后电位。支配2型细胞的节前神经纤维通过它们之间形成的某种反馈通路被激活。因此，当通过直接细胞内刺激激活这些细胞时，似乎会诱导2型细胞的反馈激活。
