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采用二氧化碳激光显微外科技术切除的脊髓髓内肿瘤:15例患者的近期经验

Intramedullary spinal cord tumors resected with CO2 laser microsurgical technique: recent experience in fifteen patients.

作者信息

Herrmann H D, Neuss M, Winkler D

机构信息

Department of Neurosurgery, University Hospital, Hamburg, West Germany.

出版信息

Neurosurgery. 1988 Mar;22(3):518-22. doi: 10.1227/00006123-198803000-00011.

Abstract

We have operated upon 15 intramedullary spinal cord tumors with the aid of a CO2 laser attached to the microscope. The operative technique is described. Most of the tumors were localized within the cervical spinal cord. Nine tumors were benign gliomas: 4 ependymomas, 1 subependymoma, 3 astrocytomas, and 1 ganglioglioma. Six were removed totally, and 3 were removed subtotally. The remaining 6 tumors consisted of 3 hemangioblastomas, 1 intramedullary neurofibroma, 1 lipoma, and 1 primary intramedullary melanoma. Neurological function postoperatively compared to the preoperative function of the upper extremities was unchanged in 13 patients (86.5%), improved in 1, and worse in 1 patient. In the lower extremities, the preoperative neurological status was unchanged in 11 patients (73.3%), improved in 1 patient, and worse in 3 patients (20%). Magnetic resonance imaging was superior to myelography and computed tomography in localizing these lesions. Enhancement with paramagnetic substances (e.g., gadolinium-DTPA) helps to localize solid tumor within cysts. Histological evaluation of small tissue biopsies or frozen section histology is unreliable. The entire lesion should be exposed in all cases, and an attempt should be made to remove the tumor totally or, if this is not possible, to resect as much of the center of the tumor as is possible until the cord is decompressed. The decision to administer further treatment is based on the histological features of the tumor.

摘要

我们借助于连接在显微镜上的二氧化碳激光对15例脊髓髓内肿瘤进行了手术。本文描述了手术技术。大多数肿瘤位于颈髓。9例为良性胶质瘤:4例室管膜瘤、1例室管膜下瘤、3例星形细胞瘤和1例节细胞胶质瘤。6例肿瘤全切,3例次全切除。其余6例肿瘤包括3例血管母细胞瘤、1例髓内神经纤维瘤、1例脂肪瘤和1例原发性髓内黑色素瘤。与术前上肢功能相比,13例患者(86.5%)术后神经功能无变化,1例改善,1例恶化。在下肢,11例患者(73.3%)术前神经状态无变化,1例改善,3例恶化(20%)。在这些病变的定位方面,磁共振成像优于脊髓造影和计算机断层扫描。使用顺磁性物质(如钆喷酸葡胺)增强有助于确定囊肿内实性肿瘤的位置。小组织活检或冷冻切片组织学的组织学评估不可靠。所有病例均应暴露整个病变,应尝试全切肿瘤,若无法全切,则应尽可能切除肿瘤中心部分,直至脊髓减压。是否进行进一步治疗的决定基于肿瘤的组织学特征。

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