猫和兔颈动脉体中单胺和分解代谢物含量的比较。

Comparison of the monoamine and catabolite content in the cat and rabbit carotid bodies.

作者信息

Armengaud C, Leitner L M, Malber C H, Roumy M, Ruckebusch M, Sutra J F

机构信息

Université Paul Sabatier, Faculté de Médecine, UA C.N.R.S. Toulouse, France.

出版信息

Neurosci Lett. 1988 Feb 15;85(1):153-7. doi: 10.1016/0304-3940(88)90446-6.

DOI:10.1016/0304-3940(88)90446-6

PMID:3129678

Abstract

The monoamine and catabolite contents of a large number of rabbit (n = 95) and cat (n = 32) carotid bodies (CBs) have been measured by high performance liquid chromatography with electrochemical detection (HPLC-ED). The dopamine (DA) content as well as that of its precursors tyrosine (TYR), dihydroxyphenylalanine (DOPA) and catabolites dihydroxyphenylacetic acid (DOPAC), homovanilic acid (HVA) were approximately equal in both species. The noradrenaline (NA) content was 10 times larger in the cat than in the rabbit CBs. Twenty-nine out of the 32 cat CBs contained more NA than DA while the reverse was true in 92 out of 95 rabbit CBs. In 11 cats the right CB was sympathectomized and its DA and NA contents were compared to those of intact contralateral organs.

摘要

通过高效液相色谱-电化学检测法（HPLC-ED）测定了大量兔（n = 95）和猫（n = 32）颈动脉体（CBs）中的单胺和代谢物含量。两种动物体内多巴胺（DA）及其前体酪氨酸（TYR）、二羟基苯丙氨酸（DOPA）以及代谢物二羟基苯乙酸（DOPAC）、高香草酸（HVA）的含量大致相等。猫颈动脉体中的去甲肾上腺素（NA）含量比兔颈动脉体中的高10倍。32个猫颈动脉体中有29个所含NA多于DA，而95个兔颈动脉体中有92个情况则相反。对11只猫的右侧颈动脉体进行了交感神经切除术，并将其DA和NA含量与完整的对侧器官进行了比较。