Internal Medicine-Oncology, The First Hospital of Jiaxing, Jiaxing city, Zhejiang province 314001, China.
Endocrine Department, The First Hospital of Jiaxing, Jiaxing city, Zhejiang province 314001, China
Biosci Rep. 2019 Jul 25;39(7). doi: 10.1042/BSR20190476. Print 2019 Jul 31.
Thrombospondin-2 (THBS2) is a secreted protein overexpressed in numerous cancers and may function as a diagnostic tumor marker. The objective of the present study was to investigate the diagnostic performance of serum THBS2 in early stage non-small-cell lung cancer (NSCLC). Serum THBS2 and Cyfra21-1 level were evaluated in blood samples of 112 patients from NSCLC groups and 51 healthy control (HC) groups. Receiver operator characteristic (ROC) curves were used to evaluate the diagnostic significance. Serum THBS2 level was significantly up-regulated in NSCLC patients compared with healthy control subjects (<0.0001), and the postoperative THBS2 level decreased significantly (<0.0001). ROC curves analysis demonstrated that THBS2 was a comparable biomarker as Cyfra21-1 to distinguish early stage NSCLC or lung squamous cell carcinoma (SC) from healthy control subjects. And Cyfra21-1 was observed with significantly improved performances by the combination of THBS2 to distinguish early stage NSCLC (<0.05) as well as SC (<0.05) from the control subjects. In addition, THBS2 was estimated to perform well in the diagnosis of patients with Cyfra21-1-negative NSCLC (area under the curve [AUC] = 0.73). In summary, the present study suggested that serum THBS2 might be an early diagnostic biomarker for NSCLC.
血栓反应蛋白-2（THBS2）是一种在多种癌症中过表达的分泌蛋白，可能作为一种诊断肿瘤标志物发挥作用。本研究的目的是研究血清 THBS2 在早期非小细胞肺癌（NSCLC）中的诊断性能。在 NSCLC 组和 51 例健康对照组的血液样本中评估了血清 THBS2 和 Cyfra21-1 水平。使用受试者工作特征（ROC）曲线评估诊断意义。与健康对照组相比，NSCLC 患者的血清 THBS2 水平显著升高（<0.0001），术后 THBS2 水平显著降低（<0.0001）。ROC 曲线分析表明，THBS2 与 Cyfra21-1 一样是一种可比较的生物标志物，可区分早期 NSCLC 或肺鳞状细胞癌（SC）与健康对照组。并且通过组合 THBS2 观察到 Cyfra21-1 能够显著提高区分早期 NSCLC（<0.05）和 SC（<0.05）的性能。此外，THBS2 被估计在诊断 Cyfra21-1 阴性 NSCLC 患者方面表现良好（曲线下面积[AUC] = 0.73）。综上所述，本研究表明血清 THBS2 可能是 NSCLC 的早期诊断生物标志物。
