退伍军人中质子泵抑制剂的使用与痴呆风险
Proton Pump Inhibitor Use and Risk of Dementia in the Veteran Population.
作者信息
Welu Jenna, Metzger Justin, Bebensee Scott, Ahrendt April, Vasek Micheal
机构信息
is a Pharmacy Resident, is Chief of Pharmacy, is a Home-Based Primary Care Clinical Pharmacy Specialist, is a Systems Redesigner, and is a Program Analyst, all at the Sioux Falls VA Health Care System in South Dakota. April Ahrendt is an Academic Assistant Professor at the University of South Dakota School of Health Sciences in Vermillion.
出版信息
Fed Pract. 2019 Jun;36(Suppl 4):S27-S31.
Abstract
There was a statistically significant association between use of proton pump inhibitors and dementia diagnosis in a 11-year retrospective study of patients at the Sioux Falls Veteran Affairs Health Care System.
摘要
在对苏福尔斯退伍军人事务医疗保健系统的患者进行的一项为期11年的回顾性研究中，质子泵抑制剂的使用与痴呆症诊断之间存在统计学上的显著关联。
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Am J Gastroenterol. 2017 Dec;112(12):1802-1808. doi: 10.1038/ajg.2017.196. Epub 2017 Jul 11.
2
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J Am Geriatr Soc. 2017 Sep;65(9):1969-1974. doi: 10.1111/jgs.14956. Epub 2017 Jun 7.
3
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