一项教育干预措施对潜在药物相互作用数量的影响。
Effect of an educational intervention on the number potential drug-drug interactions.
作者信息
Mussina Aigul Z, Smagulova Gaziza A, Veklenko Galina V, Tleumagambetova Bibigul B, Seitmaganbetova Nazgul A, Zhaubatyrova Aigul A, Zhamaliyeva Lazzat M
机构信息
Department of Propedeutics of Internal Diseases and Clinical Pharmacology, West Kazakhstan Marat Ospanov State Medical University, Abulhair Khan Avenue, 21-1-30, Aktobe 030020, Kazakhstan.
Department of Propedeutics of Internal Diseases and Clinical Pharmacology, West Kazakhstan Marat Ospanov State Medical University, Alia Moldagulova Avenue, 47-84, Aktobe 030000, Kazakhstan.
出版信息
Saudi Pharm J. 2019 Jul;27(5):717-723. doi: 10.1016/j.jsps.2019.04.007. Epub 2019 Apr 8.
BACKGROUND
The objective of this study was to evaluate effect of an Educational intervention on the number Potential Drug-Drug Interactions in the Emergency Hospital.
METHODS
The prevalence and structure of Major Drug-Drug Interactions at Emergency care Hospitals of Aktobe, Uralsk, Atyrau cities (Kazakhstan) were studied (pharmacoepidemiological, cross-sectional study). Educational interventions were developed and implemented to improve pharmacotherapy in the Cardiology Department of the Aktobe Emergency Hospital, followed by an assessment of their effect.
RESULTS
The effect of educational interventions was revealed, which led to a significant decrease in the indicators of drug interactions of the Major Drug-Drug Interactions by 18.2% (OR: 0.45; 95% CI, 0.25-to-0.82) in the cardiological patients of the Emergency Care Hospital of Aktobe city compared to the Regional Cardiology Center of Uralsk.
CONCLUSION
The implementation of educational pharmacotherapy programs decreased the number of clinically significant drug interactions in the Cardiology Department of Emergency Hospitals.
背景
本研究的目的是评估一项教育干预措施对急诊医院潜在药物相互作用数量的影响。
方法
对阿克托别、乌拉尔斯克、阿特劳市（哈萨克斯坦）急诊医院主要药物相互作用的患病率和结构进行了研究（药物流行病学横断面研究）。制定并实施了教育干预措施，以改善阿克托别急诊医院心内科的药物治疗，随后对其效果进行评估。
结果
揭示了教育干预措施的效果，与乌拉尔斯克地区心脏病中心相比，阿克托别市急诊医院心内科患者中主要药物相互作用的药物相互作用指标显著降低了18.2%（比值比：0.45；95%置信区间，0.25至0.82）。
结论
实施教育性药物治疗方案减少了急诊医院心内科具有临床意义的药物相互作用的数量。
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