Antoni Ferenc A
Centre for Discovery Brain Sciences, Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Front Endocrinol (Lausanne). 2019 Jun 26;10:422. doi: 10.3389/fendo.2019.00422. eCollection 2019.
It is now widely accepted that magnocellular vasopressinergic neurons in the supraoptic and paraventricular nuclei participate in the control of adrenocorticotropin secretion by the anterior pituitary gland. However, it remains to be explored in further detail, when and how these multifunctional neurons are involved in the control of anterior pituitary function. This paper highlights the role of magnocellular vasopressin in the hypothalamic pituitary adrenocortical axis with special reference to escape from glucocorticoid feedback inhibition. The signaling mechanisms underlying glucocorticoid escape by pituitary corticotrope cells, as well as the wider physiologic and pathologic contexts in which escape is known to occur-namely strenuous exercise, and autoimmune inflammation will be considered. It is proposed that by inducing escape from glucocorticoid feedback inhibition at the pituitary level, magnocellular vasopressin is critically important for the anti-inflammatory, and immunosuppressant actions of endogenous corticosteroids.
目前人们普遍认为，视上核和室旁核中的大细胞血管加压素能神经元参与了垂体前叶促肾上腺皮质激素分泌的调控。然而，这些多功能神经元何时以及如何参与垂体前叶功能的调控，仍有待进一步详细探究。本文着重阐述了大细胞血管加压素在下丘脑-垂体-肾上腺皮质轴中的作用，特别提及了从糖皮质激素反馈抑制中逃逸的情况。我们将探讨垂体促肾上腺皮质激素细胞糖皮质激素逃逸的信号传导机制，以及已知会发生逃逸的更广泛生理和病理背景，即剧烈运动和自身免疫性炎症。有人提出，通过在垂体水平诱导从糖皮质激素反馈抑制中逃逸，大细胞血管加压素对于内源性皮质类固醇的抗炎和免疫抑制作用至关重要。
