Wu Huilan, Ling Hong-Qing
The State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Front Plant Sci. 2019 Jun 26;10:844. doi: 10.3389/fpls.2019.00844. eCollection 2019.
Iron, as an essential micronutrient, is required by all living organisms. In plants, the deficiency and excess of iron will impair their growth and development. For maintaining a proper intracellular iron concentration, plants evolved different regulation mechanisms to tightly control iron uptake, translocation and storage. FIT, a bHLH transcription factor, is the master regulator of the iron deficiency responses and homeostasis in Arabidopsis. It interacts with different proteins, functioning in controlling the expression of various genes involved in iron uptake and homeostasis. In this review, we summarize the recent progress in the studies of FIT and FIT-binding proteins, and give an overview of FIT-regulated network in iron deficiency response and homeostasis.
铁作为一种必需的微量营养素，是所有生物所必需的。在植物中，铁的缺乏和过量都会损害其生长发育。为了维持适当的细胞内铁浓度，植物进化出不同的调节机制来严格控制铁的吸收、转运和储存。FIT是一种bHLH转录因子，是拟南芥缺铁反应和铁稳态的主要调节因子。它与不同的蛋白质相互作用，在控制参与铁吸收和铁稳态的各种基因的表达中发挥作用。在这篇综述中，我们总结了FIT及其结合蛋白研究的最新进展，并概述了缺铁反应和铁稳态中FIT调节的网络。
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