Hong Wei, Wang Xian, Yu Xin-Min, Chen Bo, Ding Guo-Jun, Zhang Yi-Ping
Department of Medical Oncology, Zhejiang Cancer Hospital, Zhejiang key laboratory of the diagnosis & treatment technology on thoracic oncology, Hangzhou, China.
Int J Clin Exp Pathol. 2012;5(5):468-71. Epub 2012 May 23.
Malignant tumors in the tonsils are usually primary. Metastases to the tonsils are extremely rare, with nearly one hundred cases reported. Herein we present an unusual case of palatine tonsillar metastasis of non-small cell lung cancer during chemotherapy. The patient was a 39-year-old man who was diagnosed as non-small lung cancer with IIIA4 staging and poor differentiated histology. After two cycles of vinorelbine and cisplatin based chemotherapy, a big mass was developed in the right palatine tonsil which was pathologically confirmed as the metastasis from the lung. There was no hemorrhage and complains except moderate foreign body sensations. No cervical lymphadenopathy and distal metastases to other organs such as brain and liver was found. Because of poor overall performance status, no radiotherapy was given. The disease progressed after docetaxel treatment. To the best of our knowledge, this is the first case with palatine tonsillar metastasis from non-small lung cancer during induction chemotherapy.
扁桃体恶性肿瘤通常为原发性。扁桃体转移极为罕见,报道的病例近百例。在此,我们报告1例非小细胞肺癌化疗期间发生腭扁桃体转移的罕见病例。患者为39岁男性,诊断为非小细胞肺癌,ⅢA4期,组织学低分化。在接受两周期长春瑞滨和顺铂化疗后,右侧腭扁桃体出现一巨大肿物,病理证实为肺转移。除有中度异物感外,无出血及不适主诉。未发现颈部淋巴结肿大及脑、肝等其他器官远处转移。由于总体状态较差,未给予放疗。多西他赛治疗后病情进展。据我们所知,这是首例诱导化疗期间发生非小细胞肺癌腭扁桃体转移的病例。