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脐尿管癌伴寡转移性骨病的多模态治疗

Multimodal therapy in urachal carcinoma with oligometastatic bone disease.

作者信息

García Alvarez C, González Alvarez R J, Plata Bello A C, Alvarez-Argüelles Cabrera H, Castro Díaz D, Concepción Masip T

机构信息

Hospital Universitario de Canarias, Spain.

出版信息

Urol Case Rep. 2019 Jun 14;26:100936. doi: 10.1016/j.eucr.2019.100936. eCollection 2019 Sep.

DOI:10.1016/j.eucr.2019.100936
PMID:31297327
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6597527/
Abstract

A 35-year-old male patient was admitted to our hospital for urachal carcinoma with oligometastatic bone disease. He received a surgical resection through the umbilical area, urachal ligament and bladder dome (partial cystectomy) and adjuvant chemotherapy based on cisplatin-gemcitabine regimens together zoledronic acid with a good tolerance, no toxicity. Nine months after surgery, our patient presented no symptoms and the metastasis had been brought under control with no apparent signs of recurrence as assessed in a follow-up CT. To our knowledge, is the first case report of a urachal carcinoma with oligometastatic bone disease who received multimodal therapy, including surgery resection.

摘要

一名35岁男性患者因脐尿管癌伴寡转移骨病入住我院。他接受了经脐部区域、脐尿管韧带和膀胱顶部的手术切除(部分膀胱切除术),并基于顺铂-吉西他滨方案联合唑来膦酸进行辅助化疗,耐受性良好,无毒性。术后9个月,患者无症状,转移已得到控制,随访CT评估无明显复发迹象。据我们所知,这是首例接受包括手术切除在内的多模式治疗的脐尿管癌伴寡转移骨病病例报告。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36b6/6597527/9f746811b72a/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36b6/6597527/e18bd7121326/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36b6/6597527/5ba5eb737f7d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36b6/6597527/9f746811b72a/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36b6/6597527/e18bd7121326/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36b6/6597527/5ba5eb737f7d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36b6/6597527/9f746811b72a/gr3.jpg

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引用本文的文献

1
Successful treatment of locally advanced urachal adenocarcinoma with peri-operative gemcitabine - cisplatin combination therapy: a case report and perspective on targeted therapies.围手术期吉西他滨 - 顺铂联合治疗成功治愈局部晚期脐尿管腺癌:一例病例报告及靶向治疗的观点
Cent European J Urol. 2020;73(4):476-481. doi: 10.5173/ceju.2020.0176. Epub 2020 Nov 20.

本文引用的文献

1
Urachal carcinoma: clinicopathological features, treatment and outcome.脐尿管癌:临床病理特征、治疗及预后
J Cancer Res Ther. 2014 Jul-Sep;10(3):571-4. doi: 10.4103/0973-1482.137955.
2
Options for diagnosis and treatment of urachal carcinoma.脐尿管癌的诊断与治疗选择。
Asia Pac J Clin Oncol. 2013 Jun;9(2):117-22. doi: 10.1111/j.1743-7563.2012.01592.x. Epub 2012 Oct 9.
3
A case of metastatic urachal adenocarcinoma treated with several different chemotherapeutic regimens.一例采用多种不同化疗方案治疗的转移性脐尿管腺癌。
Can Urol Assoc J. 2012 Feb;6(1):E27-31. doi: 10.5489/cuaj.11109.
4
Urachal carcinoma: clinicopathologic features and long-term outcomes of an aggressive malignancy.脐尿管癌:一种侵袭性恶性肿瘤的临床病理特征及长期预后
Cancer. 2006 Aug 15;107(4):712-20. doi: 10.1002/cncr.22060.
5
Multimodality management of urachal carcinoma: the M. D. Anderson Cancer Center experience.脐尿管癌的多模式管理:MD安德森癌症中心的经验
J Urol. 2003 Apr;169(4):1295-8. doi: 10.1097/01.ju.0000054646.49381.01.