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Editorial: The Development of New Classes of Hypoxia Mimetic Agents for Clinical Use.

作者信息

Chen Ruoli, Forsyth Nicholas

机构信息

School of Pharmacy and Bioengineering, Keele University, Staffordshire, United Kingdom.

出版信息

Front Cell Dev Biol. 2019 Jun 26;7:120. doi: 10.3389/fcell.2019.00120. eCollection 2019.

DOI:10.3389/fcell.2019.00120
PMID:31297372
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6607106/
Abstract
摘要

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2
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Patients with obstructive sleep apnea present with chronic upregulation of serum HIF-1α protein.阻塞性睡眠呼吸暂停患者存在血清低氧诱导因子-1α蛋白的慢性上调。
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本文引用的文献

1
Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials.临床试验中HIF脯氨酰羟化酶抑制剂的分子和细胞机制
Chem Sci. 2017 Nov 1;8(11):7651-7668. doi: 10.1039/c7sc02103h. Epub 2017 Sep 11.
2
Hypoxia Inducible Factor (HIF) transcription factor family expansion, diversification, divergence and selection in eukaryotes.真核生物中缺氧诱导因子（HIF）转录因子家族的扩张、多样化、分化及选择
PLoS One. 2017 Jun 14;12(6):e0179545. doi: 10.1371/journal.pone.0179545. eCollection 2017.
3
Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice.个体脯氨酰-4-羟化酶同工型在短暂性局灶性脑缺血后 24 小时内的作用：来自基因修饰小鼠的见解。
J Physiol. 2012 Aug 15;590(16):4079-91. doi: 10.1113/jphysiol.2012.232884. Epub 2012 May 21.
4
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia.缺氧诱导因子脯氨酰羟化酶2是在常氧状态下使缺氧诱导因子-1α维持低稳态水平的关键氧感受器。
EMBO J. 2003 Aug 15;22(16):4082-90. doi: 10.1093/emboj/cdg392.
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A conserved family of prolyl-4-hydroxylases that modify HIF.一个修饰缺氧诱导因子的脯氨酰-4-羟化酶保守家族。
Science. 2001 Nov 9;294(5545):1337-40. doi: 10.1126/science.1066373. Epub 2001 Oct 11.
6
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.一种通过从头合成蛋白质由缺氧诱导的核因子，在转录激活所需的位点与人类促红细胞生成素基因增强子结合。
Mol Cell Biol. 1992 Dec;12(12):5447-54. doi: 10.1128/mcb.12.12.5447-5454.1992.