Bobba V S, Mittal B B, Hoover S V, Kepka A
Radiology Oncology Center, Northwestern Memorial Hospital, Chicago, IL 60611.
Radiology. 1988 Jun;167(3):849-52. doi: 10.1148/radiology.167.3.3129752.
Classical and anaplastic seminoma are traditionally treated with radiation therapy and are said to have the same prognosis. A retrospective study was undertaken of 90 seminoma patients treated with radiation therapy between 1961 and 1985. The classical group consisted of 71 patients of whom 50 had stage I and 21 had stage II disease. The anaplastic group consisted of 19 patients of whom ten had stage I and nine had stage II disease. The median follow-up time was 64 months for the entire group. The 10-year relapse-free survival rate for the classical group was 94% and for the anaplastic group was 70% (P less than .05). For patients with classical stage I disease, the relapse-free actuarial survival rate was 98%; for patients with anaplastic stage I disease, it was 64% (P less than .02). For the classical stage II disease group, the relapse-free actuarial survival rate was 84% and for the anaplastic stage II disease group, 75% (P less than .70). Four patients in the classical group (6%) had relapses; of these, one patient had local recurrence of tumor, and three had distant metastases. In the anaplastic group, four patients (21%) had relapses; two patients had local recurrence of tumor, and two had distant metastases. Therefore the data suggest a difference in survival and relapse rates between classical and anaplastic seminoma.
经典型和间变性精原细胞瘤传统上采用放射治疗，据说预后相同。对1961年至1985年间接受放射治疗的90例精原细胞瘤患者进行了一项回顾性研究。经典型组由71例患者组成，其中50例为I期，21例为II期疾病。间变性组由19例患者组成，其中10例为I期，9例为II期疾病。整个组的中位随访时间为64个月。经典型组的10年无复发生存率为94%，间变性组为70%（P小于0.05）。对于经典型I期疾病患者，无复发精算生存率为98%；对于间变性I期疾病患者，为64%（P小于0.02）。对于经典型II期疾病组，无复发精算生存率为84%，间变性II期疾病组为75%（P小于0.70）。经典型组中有4例患者（6%）复发；其中，1例患者肿瘤局部复发，3例有远处转移。在间变性组中，4例患者（21%）复发；2例患者肿瘤局部复发，2例有远处转移。因此，数据表明经典型和间变性精原细胞瘤在生存率和复发率上存在差异。
