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脊髓损伤患者肾结石的治疗结果。

Outcomes of renal calculi in patients with spinal cord injury.

机构信息

Department of Urology, University of Michigan, Ann Arbor, Michigan.

Department of Urology, University of Minnesota, Minneapolis, Minnesota.

出版信息

Neurourol Urodyn. 2019 Sep;38(7):1901-1906. doi: 10.1002/nau.24091. Epub 2019 Jul 11.

Abstract

AIMS

Patients with spinal cord injury (SCI) are at risk of developing renal calculi. This study describes the management of renal calculi among patients with SCI with attention to factors influencing surgical management vs observation.

METHODS

This retrospective, cohort study identified patients with SCI and renal calculi between 2009 to 2016 from an institutional neurogenic bladder database and detailed the management of their stones. A stone episode was defined as radiographic evidence of new calculi.

RESULTS

Of 205 patients with SCI, 34 had renal stones, for a prevalence of 17%. The mean age was 50 years (range 22,77) and most had cervical SCI (n = 22, 65%). There were 41 stone episodes with 98 individual stones identified with a mean stone size of 4.9 mm (range 1-19). Of the 41 episodes, 10 (24%) underwent surgery after initial diagnosis. Pain was the most common primary indication for surgery (n = 9, 60%). The median time from diagnosis to intervention for all patients was 4 months (interquartile range 1,23). Of the 41 episodes, 31 (76%) were initially observed and among these, 5 ultimately required surgery (16%) while 26 (84%) did not. Of these 26, 12 (46%) stones passed spontaneously and 14 (53%) remained unchanged. The need for surgery correlated with more stone episodes (P = .049).

CONCLUSION

In this cohort of patients with SCI and small, nonobstructing renal stones, 76% (n = 31) were offered observation. Of these observed patients, 84% (n = 26) did not require further intervention at a median of 4 years of follow-up.

摘要

目的

脊髓损伤 (SCI) 患者存在形成肾结石的风险。本研究描述了 SCI 患者肾结石的治疗方法,重点关注影响手术治疗与观察治疗选择的因素。

方法

本回顾性队列研究从一个机构性神经源性膀胱数据库中确定了 2009 年至 2016 年期间患有 SCI 和肾结石的患者,并详细记录了他们结石的治疗情况。结石发作定义为新结石的影像学证据。

结果

在 205 名 SCI 患者中,有 34 名患者发生肾结石,患病率为 17%。患者的平均年龄为 50 岁(范围 22-77 岁),且大多数为颈髓损伤(n=22,65%)。共发生 41 次结石发作,共发现 98 个结石,平均结石大小为 4.9mm(范围 1-19mm)。在 41 次发作中,10 次(24%)在初次诊断后接受了手术。疼痛是手术最常见的主要指征(n=9,60%)。所有患者从诊断到干预的中位时间为 4 个月(四分位距 1-23 个月)。在 41 次发作中,31 次(76%)最初接受了观察治疗,其中 5 次最终需要手术(16%),而 26 次(84%)不需要手术。在这 26 次中,12 次(46%)结石自行排出,14 次(53%)无变化。需要手术与更多的结石发作相关(P=0.049)。

结论

在本队列中,患有 SCI 和小的非梗阻性肾结石的患者中,76%(n=31)接受了观察治疗。在这些接受观察治疗的患者中,84%(n=26)在中位 4 年的随访中无需进一步干预。

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