Kruithof E K, Gudinchet A, Bachmann F
Department of Medicine, University Hospital Center, CHUV, Lausanne, Switzerland.
Thromb Haemost. 1988 Feb 25;59(1):7-12.
The association of increased PA-inhibitor (PAI) activity and of PAI-1 and PAI-2 antigen levels with different pathological conditions was studied in a collective of over 300 patients. PAI-1 and PAI-2 levels were measured by specific radioimmunoassays. A good correlation was observed of PAI activity with PAI-1 antigen (r = 0.718; p less than 0.0001) but not with PAI-2 (r = 0.070; n.s.). Both in the controls and in the patients, PAI activity and PAI-1 antigen showed an extremely large range of values. PAI activity ranged from 0.5 to 68 U/ml and PAI-1 antigen from 6 to 600 ng/ml. Increased PAI activity and PAI-1 antigen was observed in patients with malignant tumors, cardiovascular or thromboembolic disease, in the postoperative phase, with hepatic insufficiency, after trauma and after extracorporeal circulation. The large spectrum of disease states with increased PAI activity and PAI-1 antigen reinforces previous suggestions that PAI-1 is an acute phase reactant. After extracorporeal circulation, PAI activity and PAI-1 concentrations strongly increased within one hour, remained elevated for at least one week and returned to preoperation values within 7 days. PAI-2 values ranged from below detection limit (15 ng/ml), observed in half of the plasmas, to 485 ng/ml in a pregnant woman. High values of PAI-2 were only observed in pregnancy.
在300多名患者群体中研究了纤溶酶原激活物抑制剂（PAI）活性增加以及PAI-1和PAI-2抗原水平与不同病理状况之间的关联。通过特异性放射免疫测定法测量PAI-1和PAI-2水平。观察到PAI活性与PAI-1抗原之间具有良好的相关性（r = 0.718；p < 0.0001），但与PAI-2无相关性（r = 0.070；无显著性差异）。在对照组和患者中，PAI活性和PAI-1抗原均显示出极大的数值范围。PAI活性范围为0.5至68 U/ml，PAI-1抗原范围为6至600 ng/ml。在患有恶性肿瘤、心血管或血栓栓塞性疾病的患者、术后阶段、肝功能不全患者、创伤后以及体外循环后的患者中观察到PAI活性和PAI-1抗原增加。PAI活性和PAI-1抗原增加的疾病状态范围广泛，这进一步支持了之前关于PAI-1是一种急性期反应物的观点。体外循环后，PAI活性和PAI-1浓度在1小时内强烈升高，至少持续1周升高，然后在7天内恢复到术前值。PAI-2值范围从在一半血浆中观察到的低于检测限（15 ng/ml）到一名孕妇中的485 ng/ml。仅在妊娠期间观察到PAI-2的高值。
