Mayné A, Joucken K, Collard E, Randour P
Department of Anaesthesiology, University Clinics of Mont Godinne, Yvoir, Belgium.
Anaesthesia. 1988 Mar;43 Suppl:97-100. doi: 10.1111/j.1365-2044.1988.tb09086.x.
Fourteen patients of ASA grades 1-3 were anaesthetised with continuous infusions of propofol and alfentanil for endoscopic carbon dioxide laser ENT microsurgery. Their lungs were ventilated with an oxygen-air mixture using a high frequency jet ventilator. Propofol was given at an initial rate of 120 micrograms/kg/minute for 10 minutes after a bolus dose of 2.6 mg/kg, and then at 80 micrograms/kg/minute. Alfentanil was given at a rate of 0.5 micrograms/kg/minute. Arterial pressure decreased significantly after the bolus dose. It increased significantly for a few minutes after laryngoscopy and returned to baseline values during maintenance of anaesthesia. Heart rate increased significantly during induction and until laryngoscopy was performed but it decreased below its initial value after 5 minutes of maintenance. Platelet count and the degree of aggregation did not change during infusion of propofol.
14例美国麻醉医师协会（ASA）1 - 3级患者接受异丙酚和阿芬太尼持续输注麻醉，用于内镜下二氧化碳激光耳鼻喉显微手术。使用高频喷射呼吸机以氧气 - 空气混合气体对其肺部进行通气。异丙酚在给予2.6mg/kg的推注剂量后，以120微克/千克/分钟的初始速率输注10分钟，然后以80微克/千克/分钟的速率输注。阿芬太尼以0.5微克/千克/分钟的速率给药。推注剂量后动脉压显著下降。喉镜检查后几分钟动脉压显著升高，并在麻醉维持期间恢复到基线值。诱导期间及直至进行喉镜检查时心率显著增加，但在维持5分钟后心率降至初始值以下。输注异丙酚期间血小板计数及聚集程度未发生变化。
