分支延伸：异型泛素链增强的信号转导。
Branching Out: Improved Signaling by Heterotypic Ubiquitin Chains.
机构信息
Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
出版信息
Trends Cell Biol. 2019 Sep;29(9):704-716. doi: 10.1016/j.tcb.2019.06.003. Epub 2019 Jul 9.
Ubiquitin chains of distinct topologies control the stability, interactions, or localization of many proteins in eukaryotic cells, and thus play an essential role in cellular information transfer. It has recently been found that ubiquitin chains can be combined to produce branched conjugates that are characterized by the presence of at least two linkages within the same polymer. Akin to their homotypic counterparts, branched chains elicit a wide array of biological outputs, further expanding the versatility, specificity, and efficiency of ubiquitin-dependent signaling. This review discusses emerging understanding of the synthesis and function of branched ubiquitin chains.
在真核细胞中，不同拓扑结构的泛素链控制着许多蛋白质的稳定性、相互作用或定位，因此在细胞信息传递中发挥着重要作用。最近发现，泛素链可以组合形成具有至少两个键的分支缀合物，这是同一聚合物中存在的特征。与同源物类似，分支链会引发广泛的生物学输出，进一步扩展了依赖泛素的信号转导的多功能性、特异性和效率。本文综述了对分支泛素链的合成和功能的新认识。
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