支化泛素链的组装和功能。
Assembly and function of branched ubiquitin chains.
机构信息
Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720, USA; California Institute for Quantitative Biosciences (QB3), University of California at Berkeley, Berkeley, CA 94720, USA.
出版信息
Trends Biochem Sci. 2022 Sep;47(9):759-771. doi: 10.1016/j.tibs.2022.04.003. Epub 2022 May 1.
Post-translational modification with ubiquitin is required for cell division, differentiation, and survival in all eukaryotes. As part of an intricate signaling code, ubiquitin is attached to its targets as single molecules or polymeric chains, with the distinct modifications encoding a wide range of outcomes. After early work focused on homotypic ubiquitin chains, such as the K48-linked polymers that drive proteasomal degradation, recent studies noted abundant conjugates that contained ubiquitin molecules modified on two or more sites. Such branched ubiquitin chains are produced in response to specific signals and they exert functions that are critical for cellular and organismal homeostasis. In this review, we will discuss our rapidly evolving understanding of the assembly and function of branched ubiquitin chains.
泛素化修饰是真核生物细胞分裂、分化和存活所必需的。作为复杂信号编码的一部分，泛素以单分子或多聚链的形式连接到其靶标上，不同的修饰方式编码了广泛的结果。在早期专注于同质泛素链的工作之后，例如驱动蛋白酶体降解的 K48 连接聚合物，最近的研究注意到含有两个或更多位点修饰的泛素分子的丰富缀合物。这种分支泛素链是对特定信号的响应产生的，它们发挥的功能对于细胞和生物体的内稳态至关重要。在这篇综述中，我们将讨论我们对分支泛素链的组装和功能的快速发展的理解。
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