Wilson Jacob M, Holzgrefe Russell E, Staley Christopher A, Schenker Mara L, Meals Clifton
Emory University Orthopedics and Spine, Atlanta, GA.
Emory University Orthopedics and Spine, Atlanta, GA.
J Hand Surg Am. 2019 Sep;44(9):742-750. doi: 10.1016/j.jhsa.2019.05.004. Epub 2019 Jul 9.
Malnutrition is known to negatively affect outcomes after arthroplasty, hip fracture, and spine surgery. Although distal radius fracture surgery may be considered in a similar patient cohort, the effect of malnutrition in this scenario is unknown. We hypothesized that admission serum albumin level, as a marker for malnutrition, would correlate with the rate of postoperative complications following surgery for distal radius fracture.
We performed a retrospective cohort study of the American College of Surgeons National Surgery Quality Improvement database. Patients undergoing open reduction and internal fixation of a distal radius fracture were identified using Current Procedural Terminology codes. We excluded patients who were septic at presentation, were multiply injured, or had open fractures. We collected patient demographics, length of stay, 30-day complications, reoperation, and readmission rates. We performed multivariable linear regression analysis controlling for age, sex, body mass index, operative time, discharge destination, and modified Frailty Index score.
We identified 1,989 patients (mean age, 56 years; range, 18-90 years) with available albumin levels, and 14.7% had hypoalbuminemia (albumin, < 3.5 g/dL). Multivariable regression revealed that malnourished patients had higher rates of postoperative complications (6.5% vs 1.3%; odds ratio [OR] 4.88; 95% confidence interval [95% CI], 2.47-9.66). Specifically, these patients had increased rates of Clavien-Dindo IV (life-threatening) complications (2.4% vs 0%), readmission (7.2% vs 2%; OR, 3.37; 95% CI, 1.88-6.03), and mortality (1.7% vs 0.1%; OR, 9.23; 95% CI, 1.55-54.87). Malnourished patients had significantly longer length of stay (3.55 vs 0.73 days). Albumin concentration was inversely associated with risk of death (OR, 0.12; 95% CI, 0.03-0.52).
Malnutrition, indicated by albumin less than 3.5 g/dL, is a powerful predictor of uncommon, but important, postoperative complications, including mortality, following surgery for distal radius fracture. Evaluation of preoperative albumin level may, therefore, help surgeons provide individualized counseling and more accurately stratify the risk of patients.
TYPE OF STUDY/LEVEL OF EVIDENCE: Prognostic II.
已知营养不良会对关节置换术、髋部骨折和脊柱手术后的预后产生负面影响。尽管桡骨远端骨折手术可能适用于类似的患者群体,但在这种情况下营养不良的影响尚不清楚。我们假设入院时血清白蛋白水平作为营养不良的标志物,将与桡骨远端骨折手术后的术后并发症发生率相关。
我们对美国外科医师学会国家外科质量改进数据库进行了一项回顾性队列研究。使用当前手术操作术语代码识别接受桡骨远端骨折切开复位内固定术的患者。我们排除了就诊时感染、多处受伤或开放性骨折的患者。我们收集了患者的人口统计学数据、住院时间、30天并发症、再次手术和再入院率。我们进行了多变量线性回归分析,控制了年龄、性别、体重指数、手术时间、出院目的地和改良虚弱指数评分。
我们确定了1989例有可用白蛋白水平的患者(平均年龄56岁;范围18 - 90岁),14.7%的患者有低白蛋白血症(白蛋白<3.5 g/dL)。多变量回归显示,营养不良的患者术后并发症发生率更高(6.5%对1.3%;比值比[OR]4.88;95%置信区间[95%CI],2.47 - 9.66)。具体而言,这些患者Clavien - Dindo IV级(危及生命)并发症发生率增加(2.4%对0%)、再入院率增加(7.2%对2%;OR,3.37;95%CI,1.88 - 6.03)以及死亡率增加(1.7%对0.1%;OR,9.23;95%CI,1.55 - 54.87)。营养不良的患者住院时间明显更长(3.55天对0.73天)。白蛋白浓度与死亡风险呈负相关(OR,0.12;95%CI,0.03 - 0.52)。
白蛋白低于3.5 g/dL表明的营养不良是桡骨远端骨折手术后不常见但重要的术后并发症(包括死亡率)的有力预测指标。因此,术前评估白蛋白水平可能有助于外科医生提供个性化咨询并更准确地分层患者风险。
研究类型/证据水平:预后性II级。