From Department of Family Medicine, Seohae Hospital, Seocheon, Republic of Korea (S-HL); Department of Family Practice and Community Health, Smoking Cessation Center, Ajou University School of Medicine, Suwon, Republic of Korea (S-HL); Department of Family Medicine, Seoul National University Hospital, Seoul, Republic of Korea (S-HA); Department of Family Medicine, Smoking Cessation Center, Dankook University College of Medicine, Cheonan, Republic of Korea (Y-SC).
J Am Board Fam Med. 2019 Jul-Aug;32(4):567-574. doi: 10.3122/jabfm.2019.04.180384.
New approaches to electronic cigarettes (e-cigarettes) as a form of nicotine replacement therapy (NRT) may reduce the rates of tobacco-related disease and mortality. Therefore, we investigated the effect of e-cigarettes on smoking cessation compared with nicotine gum.
A total of 150 subjects were randomly assigned to 2 groups and each was allocated a 12-week supply of either e-cigarettes or nicotine gum. The continuous abstinence rate, 7-day point prevalence of abstinence, smoking reduction rate and amount, and tolerability were evaluated.
There were no statistically significant differences in the effectiveness-related parameters of smoking cessation, such as 9- to 12-week, 9- to 24-week, and 12- and 24-week point prevalence of abstinence, between the 2 groups. However, although the reduction in cigarette smoking was similar, the proportion of subjects who showed smoking reduction at 24 weeks was higher in the e-cigarette group than the nicotine gum group. In addition, adverse events were significantly less frequent in the e-cigarette group than in the nicotine gum group.
In our study, the effect of e-cigarettes on smoking cessation was similar compared with that of nicotine gum, a well-documented NRT. In addition, e-cigarettes were well tolerated by the study population. Therefore, the use of e-cigarettes as an NRT may be considered for smoking-cessation purposes. A large-scale prospective randomized controlled trial is necessary to clarify our results.
电子烟作为尼古丁替代疗法（NRT）的一种新方法可能会降低与烟草相关的疾病和死亡率。因此，我们研究了电子烟在戒烟方面的效果，将其与尼古丁口香糖进行比较。
共 150 名受试者被随机分为 2 组，每组均分配 12 周的电子烟或尼古丁口香糖供应。评估持续戒烟率、7 天戒烟点流行率、吸烟减少率和数量以及耐受性。
在戒烟的有效性相关参数方面，如 9 至 12 周、9 至 24 周以及 12 至 24 周的戒烟点流行率，两组之间没有统计学上的显著差异。然而，尽管吸烟量减少相似，但在 24 周时显示吸烟量减少的受试者比例在电子烟组中高于尼古丁口香糖组。此外，电子烟组的不良事件明显少于尼古丁口香糖组。
在我们的研究中，电子烟在戒烟方面的效果与尼古丁口香糖相似，尼古丁口香糖是一种经过充分证实的 NRT。此外，电子烟被研究人群很好地耐受。因此，电子烟可被考虑作为一种 NRT 用于戒烟。需要进行大规模的前瞻性随机对照试验来澄清我们的结果。
