Ho P, Wu G
Nankai University, Tinajin, China.
Biomater Artif Cells Artif Organs. 1987;15(1):199-205. doi: 10.3109/10731198709118520.
Three copolymers were made from the suspension polymerization of methyl acrylate, divinyl benzene and triallyl isocyanurate; acrylamide and N,N'-methylene-bis-acrylamide; and styrene and divinyl benzene. These copolymers were then converted into derivatives of hydrazides through several steps. They were used as polymeric sorbents. They sorbed in situ a little bit less than 40 mg. of urea per gram of sorbent at 37 degrees C, pH = 7.0-7.4 and the percentage of urea in the buffer solution being 130 mg%. The sorption of urea was related to the specific surface area of the sorbent, temperature of sorption and time of sorption, concentration of urea, pH value of solution etc. In order to find out whether the above-prepared derivatives of hydrazide can be used clinically as polymeric sorbents in artificial kidney system, the junior author carried out experiments with patient's dialysate as imitated to hemodialysis. From the results, it indicates the sorbents might be used in artificial kidney system because they sorbed the urea from hemodialysate as much as that of the pure urea in a buffer solution.
通过丙烯酸甲酯、二乙烯基苯和三烯丙基异氰脲酸酯的悬浮聚合；丙烯酰胺和N,N'-亚甲基双丙烯酰胺；以及苯乙烯和二乙烯基苯制备了三种共聚物。然后通过几步将这些共聚物转化为酰肼衍生物。它们被用作聚合物吸附剂。在37℃、pH = 7.0 - 7.4且缓冲溶液中尿素百分比为130mg%的条件下，每克吸附剂原位吸附尿素略少于40mg。尿素的吸附与吸附剂的比表面积、吸附温度、吸附时间、尿素浓度、溶液pH值等有关。为了弄清楚上述制备的酰肼衍生物是否可在临床上用作人工肾系统中的聚合物吸附剂，第一作者以患者透析液模拟血液透析进行了实验。结果表明，这些吸附剂可能用于人工肾系统，因为它们从血液透析液中吸附的尿素量与缓冲溶液中纯尿素的吸附量相当。
