脑血管疾病中组织间液和细胞外基质的成像：当前观点与临床应用
Imaging Interstitial Fluids and Extracellular Matrix in Cerebrovascular Disorders: Current Perspectives and Clinical Applications.
作者信息
McGee Talkington Grant, Ouvrier Blake, White Amanda Louise, Hall Gregory, Umar Meenakshi, Bix Gregory Jaye
机构信息
Department of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA 70112, USA; Tulane Brain Institute, Tulane University, New Orleans, LA 70112, USA.
Department of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA 70112, USA; Tulane Brain Institute, Tulane University, New Orleans, LA 70112, USA.
出版信息
Neuroimaging Clin N Am. 2025 May;35(2):181-189. doi: 10.1016/j.nic.2025.01.001. Epub 2025 Feb 20.
This article provides a comprehensive review of current neuroimaging techniques for visualizing and quantifying extracellular matrix (ECM) components and interstitial fluid (ISF) dynamics in cerebrovascular disorders. It examines how alterations in ECM composition and ISF movement patterns correlate with various cerebrovascular pathologies, including ischemic stroke, frontotemporal dementia, cerebral small vessel disease, Alzhheimer's disease, and vascular dementia. The review emphasizes novel imaging markers specific to ECM/ISF alterations and their utility in differentiating various cerebrovascular pathologies. Special attention is given to the clinical applications of these imaging techniques for early disease detection, monitoring progression, and guiding therapeutic interventions.
本文全面综述了当前用于可视化和量化脑血管疾病中细胞外基质（ECM）成分和细胞间液（ISF）动力学的神经成像技术。研究了ECM组成的改变和ISF运动模式如何与各种脑血管疾病相关，包括缺血性中风、额颞叶痴呆、脑小血管疾病、阿尔茨海默病和血管性痴呆。该综述强调了特定于ECM/ISF改变的新型成像标志物及其在区分各种脑血管疾病中的效用。特别关注这些成像技术在疾病早期检测、监测进展和指导治疗干预方面的临床应用。
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