Institute of Anatomy, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria; Chondrometrics GmbH, Ainring, Germany.
Institute of Anatomy, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria; Chondrometrics GmbH, Ainring, Germany.
Osteoarthritis Cartilage. 2019 Nov;27(11):1663-1668. doi: 10.1016/j.joca.2019.06.013. Epub 2019 Jul 10.
To develop a model of early osteoarthritis, by examining whether radiographically normal knees with contralateral joint space narrowing (JSN), but without contralateral trauma history, display greater longitudinal cartilage composition change (transverse relaxation time; T2) than subjects with bilaterally normal knees.
120 radiographically normal knees (Kellgren Lawrence grade [KLG] 0) from the Osteoarthritis Initiative were studied. 60 case knees displayed definite contralateral radiographic knee osteoarthritis (KLG ≥ 2) whereas 60 reference subjects were bilaterally KLG0, and were matched 1:1 to cases based on age, sex, and BMI. All had multi-echo spin-echo MRI acquired at year (Y) 1 and 4 follow-up, with cartilage T2 being determined in superficial and deep cartilage layers across 16 femorotibial subregions. T2 across all regions was considered the primary analytic focus.
Of 60 KLG0 case knees (30 female, age: 65.0 ± 8.8 y, BMI: 27.6 ± 4.4 kg/m), 21/22/13/4 displayed contralateral JSN 0/1/2/3, respectively. The longitudinal increase in the deep layer cartilage T2 between Y1 and Y4 was significantly greater (P = 0.03; Cohen's D 0.50) in the 39 KLG0 case knees with contralateral JSN (1.2 ms; 95% confidence interval [CI] [0.4, 2.0]) than in matched KLG0 reference knees (0.1 ms; 95% CI [-0.5, 0.7]). No significant differences were identified in superficial T2 change. T2 at Y1 was significantly greater in case than in reference knees, particularly in the superficial layer of the medial compartment.
Radiographically normal knees with contralateral, non-traumatic JSN represent an applicable model of early osteoarthritis, with deep layer cartilage composition (T2) changing more rapidly than in bilaterally normal knees. CLINICALTRIALS.
NCT00080171.
通过检查是否存在对侧关节间隙变窄（JSN）但无对侧创伤史的影像学正常膝关节，研究是否存在比双侧膝关节正常的受试者具有更大的纵向软骨成分变化（横向弛豫时间；T2）的早期骨关节炎模型。
研究了来自骨关节炎倡议的 120 个影像学正常膝关节（Kellgren-Lawrence 分级 [KLG] 0）。60 例病例膝关节显示明确的对侧膝关节骨关节炎（KLG≥2），而 60 例参考对象双侧 KLG0，并根据年龄、性别和 BMI 与病例 1:1 匹配。所有患者在第 1 年（Y）和第 4 年随访时均接受多回波自旋回波 MRI 检查，在 16 个股骨胫骨亚区的浅层和深层软骨中确定软骨 T2。所有区域的 T2 被认为是主要分析焦点。
在 60 个 KLG0 病例膝关节（30 名女性，年龄：65.0±8.8 岁，BMI：27.6±4.4 kg/m2）中，21/22/13/4 例分别显示对侧 JSN 0/1/2/3。在 Y1 至 Y4 之间，深层软骨 T2 的纵向增加在具有对侧 JSN 的 39 个 KLG0 病例膝关节中明显更大（P=0.03；Cohen's D 0.50）（1.2 ms；95%置信区间 [CI] [0.4, 2.0]）比在匹配的 KLG0 参考膝关节中（0.1 ms；95% CI [-0.5, 0.7]）。在浅层 T2 变化中未发现显著差异。病例膝关节的 T2 在 Y1 时明显大于参考膝关节，尤其是在内侧间室的浅层。
存在对侧、非创伤性 JSN 的影像学正常膝关节代表了早期骨关节炎的一种适用模型，与双侧正常膝关节相比，深层软骨成分（T2）的变化更快。
临床试验。
NCT00080171。
