Paracelsus Medical University Salzburg and Nuremberg, Salzburg, Austria, and Chondrometrics, Ainring, Germany.
Paracelsus Medical University Salzburg and Nuremberg, Salzburg, Austria.
Arthritis Care Res (Hoboken). 2022 Nov;74(11):1888-1893. doi: 10.1002/acr.24627. Epub 2022 Jul 12.
To study whether layer-specific cartilage transverse relaxation time (T2) and/or longitudinal change is associated with clinically relevant knee osteoarthritis (OA) disease progression.
The Foundation for the National Institutes of Health Biomarker Consortium was a nested case-control study on 600 knees from 600 Osteoarthritis Initiative participants. Progressor knees had both medial tibiofemoral radiographic joint space width (JSW) loss (≥0.7 mm) and a persistent increase in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain score (≥9 on a 0-100 scale) at 24-48 months from baseline (n = 194). Multiecho spin-echo (MESE) magnetic resonance images (MRIs) for cartilage T2 analysis had been acquired in the right knees only (97 progressor knees). These were compared to 104 control knees without JSW or pain progression. Fifty-three knees had JSW progression, and 57 pain progression only. Cartilage thickness segmentations obtained from double-echo steady-state MRI were matched to MESE MRI to extract superficial and deep femorotibial cartilage T2. Superficial medial femorotibial compartment (MFTC) T2 at baseline was the primary, and change in deep MFTC T2 between baseline and 12 months was the secondary analytic outcome of this post hoc exploratory study.
Baseline superficial MFTC T2 was significantly elevated in progressor knees (adjusted mean 47.2 msec [95% confidence interval (95% CI) 46.5, 48.0]) and JSW progression only knees (adjusted mean 47.3 msec [95% CI 46.3, 48.3]), respectively, versus non-progressor knees (45.8 msec [95% CI 45.0, 46.5]) after adjustment for age, sex, body mass index, WOMAC pain score, and medial joint space narrowing grade (analysis of covariance). Change in T2 was not significantly associated with case status.
Baseline superficial, but not deep, medial cartilage T2 is associated with clinically relevant disease progression in knee OA.
研究软骨各层的横向弛豫时间（T2）和/或纵向变化是否与临床相关的膝骨关节炎（OA）疾病进展有关。
美国国立卫生研究院生物标志物联盟是一项嵌套病例对照研究，共纳入 600 名来自 Osteoarthritis Initiative 研究的参与者的 600 个膝关节。进展组膝关节在基线后 24-48 个月时，均出现内侧胫股关节间隙宽度（JSW）损失（≥0.7 毫米）和 Western Ontario and McMaster Universities Osteoarthritis Index（WOMAC）疼痛评分持续增加（0-100 分制≥9 分）（n=194）。仅在右膝采集了用于软骨 T2 分析的多回波自旋回波（MESE）磁共振成像（MRI）（97 个进展组膝关节）。这些与 104 个无 JSW 或疼痛进展的对照组膝关节进行比较。53 个膝关节有 JSW 进展，57 个只有疼痛进展。从双回波稳态 MRI 获得的软骨厚度分割与 MESE MRI 相匹配，以提取股骨胫骨关节的浅层和深层软骨 T2。基线时的浅层内侧股骨胫骨间室（MFTC）T2 是本事后探索性研究的主要分析结果，而基线和 12 个月之间深层 MFTC T2 的变化是次要分析结果。
进展组膝关节（调整后的平均 47.2 毫秒[95%置信区间（95%CI）46.5，48.0]）和仅 JSW 进展组膝关节（调整后的平均 47.3 毫秒[95%CI 46.3，48.3]）的基线时浅层 MFTC T2 明显升高，与非进展组膝关节（45.8 毫秒[95%CI 45.0，46.5]）相比，校正年龄、性别、体重指数、WOMAC 疼痛评分和内侧关节间隙变窄分级（协方差分析）后。T2 的变化与病例状态无显著相关性。
基线时的浅层，但不是深层，内侧软骨 T2 与膝骨关节炎的临床相关疾病进展有关。
