Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada; Richardson Centre for Functional Foods and Nutraceuticals (RCFFN), University of Manitoba, Winnipeg, Manitoba, Canada.
Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada; Richardson Centre for Functional Foods and Nutraceuticals (RCFFN), University of Manitoba, Winnipeg, Manitoba, Canada.
Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Nov;1864(11):1563-1579. doi: 10.1016/j.bbalip.2019.07.002. Epub 2019 Jul 10.
The discovery of N‑acylethanolamines (NAEs) has prompted an increase in research aimed at understanding their biological roles including regulation of appetite and energy metabolism. However, a knowledge gap remains to understand the effect of dietary components on NAE levels, in particular, heterogeneity in dietary fatty acid (DFA) profile, on NAE levels across various organs.
To identify and elucidate the impact of diet on NAE levels in seven different tissues/organs of male hamsters, with the hypothesis that DFA will act as precursors for NAE synthesis in golden Syrian male hamsters.
A two-month feeding trial was performed, wherein hamsters were fed various dietary oil blends with different composition of 18-C fatty acid (FA).
DFA directly influences tissue FA and NAE levels. After C18:1n9-enriched dietary treatments, marked increases were observed in duodenal C18:1n9 and oleoylethanolamide (OEA) concentrations. Among all tissues; adipose tissue brown, adipose tissue white, brain, heart, intestine-duodenum, intestine-jejunum, and liver, a negative correlation was observed between gut-brain OEA concentrations and body weight.
DFA composition influences FA and NAE levels across all tissues, leading to significant shifts in intestinal-brain OEA concentrations. The endogenously synthesized increased OEA levels in these tissues enable the gut-brain-interrelationship. Henceforth, we summarize that the brain transmits anorexic properties mediated via neuronal signalling, which may contribute to the maintenance of healthy body weight. Thus, the benefits of OEA can be enhanced by the inclusion of C18:1n9-enriched diets, pointing to the possible nutritional use of this naturally occurring bioactive lipid-amide in the management of obesity.
N-酰基乙醇胺（NAE）的发现促使人们增加了对其生物学作用的研究，包括对食欲和能量代谢的调节。然而，人们对饮食成分对 NAE 水平的影响，特别是饮食脂肪酸（DFA）谱的异质性对各种器官 NAE 水平的影响，仍存在知识空白。
确定并阐明饮食对雄性金黄叙利亚仓鼠七种不同组织/器官中 NAE 水平的影响，假说为 DFA 将作为 NAE 合成的前体在金黄叙利亚雄性仓鼠中发挥作用。
进行了为期两个月的喂养试验，其中仓鼠喂食不同组成的 18-C 脂肪酸（FA）的各种饮食油混合物。
DFA 直接影响组织 FA 和 NAE 水平。在富含 C18:1n9 的饮食处理后，十二指肠 C18:1n9 和油酰乙醇胺（OEA）浓度明显增加。在所有组织中；棕色脂肪组织、白色脂肪组织、大脑、心脏、肠-十二指肠、肠-空肠和肝脏，肠道-大脑 OEA 浓度与体重之间呈负相关。
DFA 组成影响所有组织的 FA 和 NAE 水平，导致肠道-大脑 OEA 浓度发生显著变化。这些组织中内源性合成的 OEA 水平增加使肠道-大脑相互关系成为可能。因此，我们总结出，大脑通过神经元信号传递厌食特性，这可能有助于保持健康的体重。因此，通过摄入富含 C18:1n9 的饮食可以增强 OEA 的益处，这表明这种天然存在的生物活性脂质酰胺在肥胖症的管理中可能具有潜在的营养用途。
