The Mental Health Center, Yunnan University, Kunming, China.
Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, 286 Guangji Road, Suzhou, Jiangsu Province, China.
J Affect Disord. 2019 Oct 1;257:200-206. doi: 10.1016/j.jad.2019.06.052. Epub 2019 Jul 2.
Anxiety is a common comorbidity in major depressive disorder (MDD) that has been studied extensively in the past. However, few studies have explored anxiety in drug naïve (FEDN) patients with MDD and those presenting with a first episode. The objective of this current study was to examine the prevalence and risk factors of anxiety in FEDN patients with MDD in order to understand the relationship between MDD and anxiety in the acute early phase and provide important implications for therapeutic interventions.
A total of 1718 FEDN patients with MDD were recruited in this cross-sectional study. Their anthropometric and clinical data, including suicide attempt and psychotic symptom, were collected. The Hamilton depression scale (HAMD) and Hamilton anxiety scale (HAMA) were used to evaluate depression and anxiety for all the patients in this study.
Overall, we found that the prevalence of anxiety in FEDN MDD patients was 80.3%. Correlation analysis showed that anxiety was associated with suicide attempt and psychotic symptom in FEDN patients with MDD. The rate of suicide attempt and psychosis in above patients with anxiety was 24.3% and 12.3%, respectively. Furthermore, stepwise regression analysis showed that suicide attempt and psychotic symptom were significant predictors for anxiety in FEDN patients with MDD.
Our study showed that the prevalence of comorbid anxiety in FEDN patients with MDD is very high. We also found that two clinical variables, suicide attempt and psychosis, are risk factors for comorbid anxiety in FEDN patients with MDD.
焦虑是重性抑郁障碍（MDD）的常见共病，过去已有广泛研究。然而，很少有研究探讨初发、未经药物治疗的 MDD（FEDN）患者的焦虑情况。本研究旨在调查 FEDN 伴 MDD 患者焦虑的发生率和危险因素，以了解 MDD 和焦虑在急性早期的关系，并为治疗干预提供重要启示。
本横断面研究共纳入 1718 例 FEDN 伴 MDD 患者。收集他们的人体测量学和临床数据，包括自杀未遂和精神病症状。本研究中的所有患者均采用汉密尔顿抑郁量表（HAMD）和汉密尔顿焦虑量表（HAMA）评估抑郁和焦虑。
总体而言，我们发现 FEDN MDD 患者焦虑的发生率为 80.3%。相关性分析显示，焦虑与 FEDN 伴 MDD 患者的自杀未遂和精神病症状有关。上述伴焦虑患者的自杀未遂和精神病发生率分别为 24.3%和 12.3%。此外，逐步回归分析显示，自杀未遂和精神病是 FEDN 伴 MDD 患者焦虑的显著预测因子。
我们的研究表明，FEDN 伴 MDD 患者共病焦虑的发生率非常高。我们还发现，自杀未遂和精神病这两个临床变量是 FEDN 伴 MDD 患者共病焦虑的危险因素。
