Zhu Yali, Yin Weijia, Ma Jun, Zhang Lin
Department of Psychiatry, Wuhan Mental Health Center, Wuhan, People's Republic of China.
Department of Psychiatry, Suzhou Guangji Hospital, Suzhou, People's Republic of China.
Neuropsychiatr Dis Treat. 2024 Nov 25;20:2267-2275. doi: 10.2147/NDT.S499392. eCollection 2024.
Anxious depression (AUD) is a common subtype of major depressive disorder (MDD) and has a significant negative impact on disease progression and patient prognosis. Our study aimed to determine the frequency of AUD in Chinese patients with MDD during their first hospitalization and to identify factors that may influence the emergence and intensity of these AUD.
This study enrolled 981 Chinese MDD patients on their inaugural hospital admission. Data on demographic details, clinical profiles, and psychological symptoms-such as depression, anxiety, psychosis, and illness severity scores-were gathered and examined.
The study found that 10.30% of the target population exhibited AUD. Compared with the non-AUD group, the AUD group had higher scores on Hamilton Depression Scale (HAMD), Positive symptom subscale of the Positive and Negative Symptom Scale (PSS), and Clinical Global Impression Scale - Severity of Illness (CGI-SI) and higher levels of fasting blood glucose (FBG), total cholesterol (TC), body mass index (BMI), systolic blood pressure (SBP) and diastolic blood pressure (DBP). In addition, higher scores of HAMD, PSS and CGI-SI were risk factors for increasing the severity of anxiety, higher TC level was contrary.
This study reveals the prevalence of AUD in hospitalized patients with MDD and identifies clinical factors that contribute to the onset and progression of AUD. Reporting these clinical features may help establish potential markers for early recognition and intervention.
焦虑抑郁(AUD)是重度抑郁症(MDD)的一种常见亚型,对疾病进展和患者预后有显著负面影响。我们的研究旨在确定中国MDD患者首次住院期间AUD的发生率,并识别可能影响这些AUD出现和严重程度的因素。
本研究纳入了981名首次入院的中国MDD患者。收集并检查了人口统计学细节、临床特征以及心理症状(如抑郁、焦虑、精神病和疾病严重程度评分)等数据。
研究发现,目标人群中有10.30%表现出AUD。与非AUD组相比,AUD组在汉密尔顿抑郁量表(HAMD)、阳性和阴性症状量表的阳性症状亚量表(PSS)以及临床总体印象量表 - 疾病严重程度(CGI-SI)上得分更高,空腹血糖(FBG)、总胆固醇(TC)、体重指数(BMI)、收缩压(SBP)和舒张压(DBP)水平也更高。此外,HAMD、PSS和CGI-SI得分较高是焦虑严重程度增加的危险因素,而较高的TC水平则相反。
本研究揭示了住院MDD患者中AUD的患病率,并确定了导致AUD发生和进展的临床因素。报告这些临床特征可能有助于建立早期识别和干预的潜在标志物。