Department of Medical, Surgical, and Experimental Sciences, University of Sassari, Sassari, Italy.
Laboratory of Cardiovascular Sciences, National Institute on Aging Intramural Research Program, NIH, Baltimore, USA.
Aging Clin Exp Res. 2020 May;32(5):781-788. doi: 10.1007/s40520-019-01260-0. Epub 2019 Jul 13.
Previous cross-sectional observation identified arterial aging, indexed as pulse-wave velocity (PWV), as a key determinant of the simultaneous multiple organ damage (heart, carotid artery, and kidney). The aim of the present cohort study is to investigate trajectories of repeated measures of PWV and traditional CV risk factors in subjects who eventually presented clinical evidence of multiple organ damage in the SardiNIA study.
Organ damage was measured in the heart (left ventricular hypertrophy, LVH), the common carotid artery (intima-media thickness > 0.9 mm and/or plaque), and the kidney (eGFR < 60 ml/min/1.73 m) of 2130 men and women of a broad age range participating the SardiNIA study. SHATS was defined as the simultaneous occurrence of all the three-organ damages. Trajectory in traditional CV risk factors and PWV was analyzed retrospectively (four observations over 9 years) according to the number of organ damage (from 0 to 3). Compared to subjects with no organ damage, after controlling for traditional CV risk factors, each 1 m/s increase in baseline PWV was accompanied by a 93% higher odds of developing SHATS; and each 1 cm/s (0.01 m/s) annual increase in PWV by a 31% greater odds of developing SHATS.
Arterial stiffness, a proxy of arterial aging that can be measured clinically as PWV, is an integrated predictive marker of multiple age-associated organ damage recognized as clinical diseases.
先前的横断面观察发现，动脉僵硬度（以脉搏波速度[PWV]为指标）是同时发生多种器官损伤（心脏、颈动脉和肾脏）的关键决定因素。本队列研究的目的是在 SardiNIA 研究中最终出现多种器官损伤临床证据的受试者中，研究 PWV 及传统心血管危险因素的重复测量轨迹。
本研究共纳入 2130 名年龄范围广泛的男性和女性，在心脏（左心室肥厚[LVH]）、颈总动脉（内膜中层厚度>0.9mm 和/或斑块）和肾脏（eGFR<60ml/min/1.73m）中测量器官损伤。SHATS 定义为同时发生三种器官损伤。根据器官损伤数量（0 至 3），回顾性分析传统心血管危险因素和 PWV 的轨迹（9 年内进行了 4 次观察）。在校正传统心血管危险因素后，与无器官损伤的受试者相比，基线 PWV 每增加 1m/s，发生 SHATS 的几率增加 93%；PWV 每年增加 1cm/s（0.01m/s），发生 SHATS 的几率增加 31%。
动脉僵硬度是一种可以用 PWV 临床测量的动脉老化的替代指标，是一种与年龄相关的多种器官损伤的综合预测标志物，这些损伤被认为是临床疾病。
