Department of Clinical Sciences, Lund University, University Hospital, Malmö, Sweden.
Department of Pharmacology, Pompidou Hospital, INSERM U970 and University Paris Descartes, Paris, France.
J Hypertens. 2018 Dec;36(12):2340-2349. doi: 10.1097/HJH.0000000000001824.
Arterial ageing is characterized by increasing arterial stiffness as measured by pulse wave velocity (PWV). This process is enhanced in participants with early vascular ageing (EVA), but slowed in participants with healthy vascular ageing (HVA). We aimed to describe characteristics of EVA and HVA in a transcontinental study including 11 cohorts.
In all, 18 490 participants from the global MARE Consortium, free of cardiovascular disease, participated with data on PWV and cardiometabolic risk factors. We defined HVA as the lowest 10% and EVA as the highest 10% of the standardized PWV distribution, adjusted for age intervals. HVA individuals were compared with the 90% of non-HVA individuals with ANCOVA, adjusted for age, sex and hypertension.
The 1723 HVA participants were at the same age as the rest of the population, more likely women (59.4 vs 57.0%), and with significantly lower levels of established cardiovascular risk factors (blood pressure, lipids, glucose). Similarly, the prevalence rate of obesity, diabetes mellitus, hypertension and the metabolic syndrome was lower in the HVA participants. In the presence of similar levels of cardiovascular risk factors, HVA participants in the 50-64 years of age group presented lower PWV 5.8 (SD 0.5) vs. 7.4 (1.4) m/s (P < 0.0001) than control individuals in the 35-49 years of age group, corresponding to an estimated difference in chronological age of 14 years.
Participants with healthy vascular ageing (HVA), belonging to the lowest end of the PWV distribution, are in general characterized by an up to 14 years estimated younger biological (vascular) age than those with higher PWV values, and have lower levels of risk factors.
动脉老化的特征是脉搏波速度（PWV）测量的动脉僵硬度增加。在早期血管老化（EVA）的参与者中，这一过程会增强，但在健康血管老化（HVA）的参与者中会减缓。我们旨在描述包括 11 个队列在内的一项洲际研究中 EVA 和 HVA 的特征。
共有来自全球 MARE 联盟的 18490 名无心血管疾病的参与者参与了这项研究，他们的数据包括 PWV 和心血管代谢危险因素。我们将 HVA 定义为标准化 PWV 分布的最低 10%，将 EVA 定义为最高 10%，并根据年龄间隔进行调整。用 ANCOVA 比较 HVA 个体与非 HVA 个体中 90%的个体，调整因素为年龄、性别和高血压。
1723 名 HVA 参与者与其余人群年龄相同，更可能为女性（59.4%比 57.0%），且已有心血管危险因素（血压、血脂、血糖）水平明显较低。同样，HVA 参与者的肥胖、糖尿病、高血压和代谢综合征的患病率也较低。在具有相似心血管危险因素水平的情况下，50-64 岁年龄组的 HVA 参与者的 PWV 为 5.8（0.5）m/s，低于 35-49 岁年龄组对照组的 7.4（1.4）m/s（P<0.0001），相当于估计的生物学（血管）年龄相差 14 岁。
属于 PWV 分布最低端的健康血管老化（HVA）参与者，其生物学（血管）年龄比 PWV 值较高的参与者平均年轻 14 岁，且危险因素水平较低。
