Military Institute of Hygiene and Epidemiology, Warsaw, Poland (Department of Microwave Safety).
Military Institute of Hygiene and Epidemiology, Warsaw, Poland (Department of Pharmacology and Toxicology).
Int J Occup Med Environ Health. 2019 Jul 15;32(4):465-474. doi: 10.13075/ijomeh.1896.01286. Epub 2019 Jul 3.
OBJECTIVES: The aim of this study, conducted at the Military Institute of Hygiene and Epidemiology in Warsaw in 2017, was to evaluate the effects of a single (15 min) and repeated (5 times for 15 min) radio-frequency radiation (RFR) exposure of 1800 MHz frequency on the analgesic efficacy of morphine in healthy rats and rats with complete Freund's adjuvant (CFA) induced inflammation. MATERIAL AND METHODS: Rats were injected intraperitoneally with morphine (MF) in the dose of 8 mg/kg or drug vehicle 15 min before RFR exposure. The authors used the plantar analgesia meter and the radiant heat paw-withdrawal test to assess the pain threshold. RESULTS: A single RFR exposure slightly influenced paw withdrawal latency (PWL) in healthy rats in the single exposure baseline group, and influenced PWL, 30 and 60 min after morphine or vehicle injection, in the repeated exposure group. There were differences between the sham-exposed groups (vehicle), 30, 60 and 90 min after injection, both in the single and repeated RFR-exposure groups. The antinociceptive effect of morphine in healthy rats was slightly decreased by RFR exposure at 60 and 90 min, both in the single and repeated exposure groups. The PWL was slightly decreased, both in the single and repeated exposure groups with inflammation (CFA and CFA/MF), at 30, 60 and 90 min, and PWL was increased in the sham-exposed groups (CFA and CFA/MF), both in the single and repeated exposure groups, at 30, 60 and 90 min. The antinociceptive effect of morphine in healthy rats was significantly increased by RFR exposure at 30 min after drug injection in the single exposure group, and increased at 30 and 60 min in the repeated exposure group. CONCLUSIONS: The authors observed a minor influence of RFR exposure on the antinociceptive effects of morphine in healthy rats after repeated exposures and a statistically significant influence of repeated exposure on morphine mediated antinociceptive effects in the inflammation group. Int J Occup Med Environ Health. 2019;32(4):465-74.
目的：本研究于 2017 年在华沙军事卫生与流行病学研究所进行，旨在评估 1800MHz 射频辐射（RFR）单次（15 分钟）和重复（5 次，每次 15 分钟）暴露对健康大鼠和完全弗氏佐剂（CFA）诱导炎症大鼠吗啡镇痛效果的影响。
材料和方法：大鼠在接受 RFR 暴露前 15 分钟腹膜内注射吗啡（MF），剂量为 8mg/kg 或药物载体。作者使用足底镇痛计和辐射热足撤退试验来评估疼痛阈值。
结果：单次 RFR 暴露轻微影响健康大鼠单次暴露基础组的足底退缩潜伏期（PWL），并影响重复暴露组吗啡或载体注射后 30 分钟和 60 分钟的 PWL。在单次和重复 RFR 暴露组中，在注射后 30、60 和 90 分钟，假暴露组（载体）之间存在差异。在健康大鼠中，吗啡的镇痛作用在单次和重复暴露组中均在 60 分钟和 90 分钟时略减弱。在单次和重复暴露组中，炎症大鼠（CFA 和 CFA/MF）在 30、60 和 90 分钟时 PWL 略有下降，而在单次和重复暴露组中，假暴露组（CFA 和 CFA/MF）在 30、60 和 90 分钟时 PWL 增加。在单次暴露组中，吗啡在健康大鼠中的镇痛作用在药物注射后 30 分钟时因 RFR 暴露而显著增强，在重复暴露组中，在 30 分钟和 60 分钟时增强。
结论：作者观察到重复 RFR 暴露对健康大鼠吗啡镇痛作用的轻微影响，以及重复暴露对炎症组吗啡介导的镇痛作用的统计学显著影响。国际职业医学与环境卫生杂志。2019;32(4):465-74。
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