Unité de Toxicologie Expérimentale, Institut National de l'Environnement Industriel et des Risques, 60550, Verneuil-en-Halatte, France.
Unité mixte PERITOX UMI-01 INERIS CHU Amiens-Picardie Hôpital Sud, 80480 Salouël, France.
Int J Environ Res Public Health. 2020 Oct 18;17(20):7563. doi: 10.3390/ijerph17207563.
The World Health Organization and the French Health Safety Agency (ANSES) recognize that the expressed pain and suffering of electromagnetic field hypersensitivity syndrome (EHS) people are a lived reality requiring daily life adaptations to cope. Mechanisms involving glutamatergic N-methyl d-aspartate (NMDA) receptors were not explored yet, despite their possible role in hypersensitivity to chemicals. Here, we hypothesized that radiofrequency electromagnetic field (RF-EMF) exposures may affect pain perception under a modulatory role played by the NMDA receptor. The rats were exposed to RF-EMF for four weeks (five times a week, at 0 (sham), 1.5 or 6 W/kg in restraint) or were cage controls (CC). Once a week, they received an NMDA or saline injection before being scored for their preference between two plates in the two-temperatures choice test: 50 °C (thermal nociception) versus 28 °C. Results in the CC and the sham rats indicated that latency to escape from heat was significantly reduced by -45% after NMDA, compared to saline treatment. Heat avoidance was significantly increased by +40% in the 6 W/kg, compared to the sham exposed groups. RF-EMF effect was abolished after NMDA treatment. In conclusion, heat avoidance was higher after high brain-averaged specific absorption rate, affording further support for possible effect of RF-EMF on pain perception. Further studies need to be performed to confirm these data.
世界卫生组织和法国卫生安全署（ANSES）认识到，电磁场超敏综合征（EHS）患者表达的疼痛和痛苦是一种现实生活，需要日常生活适应来应对。尽管谷氨酸能 N-甲基-D-天冬氨酸（NMDA）受体可能在对化学物质过敏中起作用，但它们的机制尚未得到探索。在这里，我们假设射频电磁场（RF-EMF）暴露可能会通过 NMDA 受体的调节作用影响疼痛感知。大鼠接受 RF-EMF 照射四周（每周五次，在约束下 0（假照）、1.5 或 6 W/kg）或作为笼对照（CC）。每周一次，在进行热痛觉和 28°C 两种温度选择测试前，它们接受 NMDA 或盐水注射，以评估它们在两个盘子之间的偏好程度：50°C（热痛觉）与 28°C。在 CC 和假照大鼠中，结果表明 NMDA 后热逃避潜伏期显著降低了 45%，而与盐水治疗相比。与假照组相比，6 W/kg 组的热回避增加了 40%。NMDA 处理后，RF-EMF 的作用被消除。总之，在大脑平均比吸收率较高的情况下，热回避更高，这进一步支持了 RF-EMF 对疼痛感知的可能影响。需要进一步研究来证实这些数据。
