一种基于智能手机的用于检测生物系统中硫烷硫的设备。
A smartphone based device for the detection of sulfane sulfurs in biological systems.
作者信息
Neill Deshka L, Chang Yu-Chung, Chen Wei, Li Lei, Xian Ming
机构信息
Department of Chemistry, Washington State University, Pullman, WA 99164, USA.
School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164, USA.
出版信息
Sens Actuators B Chem. 2019 Aug 1;292:263-269. doi: 10.1016/j.snb.2019.04.099. Epub 2019 Apr 24.
Sulfane sulfur species are newly recognized signaling molecules that play physiological roles in many biological events. The development of new technologies for the detection of sulfane sulfurs is important. Point-of-care (POC) devices are in-field rapid and low-cost detectors that are more convenient to use than bulky and expensive standard instruments. In this report, a new fluorescent probe (SSP5) was designed to detect sulfane sulfurs using a POC sulfane sulfur smartphone spectrum apparatus (S4A). This probe proved to be sensitive and selective for sulfane sulfur species over other biologically relevant sulfur species such as cysteine and HS. The low-cost and compact S4A has achieved comparable performance to standard laboratory equipment in both a standard buffer system and a synthetic urine system. The proposed system (SSP5 + S4A) has the potential for high accuracy and rapid detection of sulfane sulfur species in remote and low resource settings.
硫化氢硫物种是新发现的信号分子，在许多生物事件中发挥生理作用。开发检测硫化氢硫的新技术很重要。即时检测（POC）设备是现场快速且低成本的检测器，比笨重且昂贵的标准仪器更便于使用。在本报告中，设计了一种新的荧光探针（SSP5），用于使用POC硫化氢硫智能手机光谱仪（S4A）检测硫化氢硫。该探针被证明对硫化氢硫物种具有敏感性和选择性，优于其他生物相关硫物种，如半胱氨酸和HS。低成本且紧凑的S4A在标准缓冲系统和合成尿液系统中均实现了与标准实验室设备相当的性能。所提出的系统（SSP5 + S4A）具有在偏远和资源匮乏地区高精度快速检测硫化氢硫物种的潜力。
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