Exman Pedro, Barroso-Sousa Romualdo, Tolaney Sara M
Breast Oncology Program, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Onco Targets Ther. 2019 Jul 2;12:5177-5187. doi: 10.2147/OTT.S184971. eCollection 2019.
Approximately 5-10% of all patients diagnosed with breast cancer have germline mutations, which make their disease more susceptible to DNA-damaging agents and a new class of drugs known as poly(ADP-ribose) polymerase (PARP) inhibitors. Talazoparib is a new PARP inhibitor that has been recently approved for use in patients with metastatic breast cancer with germline mutations after a phase III trial showed superior progression-free survival when compared to standard chemotherapy. In this review, we analyze the development of talazoparib as well as its safety profile and the potential role of the combination therapy with standard cytotoxic drugs and with novel therapies.
在所有被诊断为乳腺癌的患者中,约5%-10%存在胚系突变,这使得他们的疾病对DNA损伤剂和一类名为聚(ADP-核糖)聚合酶(PARP)抑制剂的新型药物更敏感。他拉唑帕尼是一种新型PARP抑制剂,在一项III期试验显示与标准化疗相比具有更好的无进展生存期后,最近已被批准用于治疗有胚系突变的转移性乳腺癌患者。在本综述中,我们分析了他拉唑帕尼的研发情况、安全性概况以及与标准细胞毒性药物和新型疗法联合治疗的潜在作用。