光催化纳米技术在医院环境中的潜在抗菌作用。

Potential antimicrobial effects of photocatalytic nanothecnologies in hospital settings.

作者信息

Margarucci L M, Romano Spica V, Protano C, Gianfranceschi G, Giuliano M, Di Onofrio V, Mucci N, Valeriani F, Vitali M, Romano F

机构信息

Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Piazza Lauro De Bosis 6, 00135 Rome, Italy.

Department of Public Health and Infectious Diseases, Sapienza University of Rome, P.le Aldo Moro, 5, 00185 Rome, Italy.

出版信息

Ann Ig. 2019 Sep-Oct;31(5):461-473. doi: 10.7416/ai.2019.2307.

DOI:10.7416/ai.2019.2307

PMID:31304526

Abstract

BACKGROUND

Recently, several advanced technologies have been considered to reduce the microbial load in hospital environments and control Healthcare Associated Infections (HAIs) incidence. New strategies for preventing HAIs have continuously evolved, including enforcement of hygiene procedures by novel liquid biocides or no-touch technologies, self-disinfecting surfaces coated by heavy metals or light-activated photosensitizers such as Titanium Dioxide (TiO2) nanoparticles.

STUDY DESIGN

Review publications concerning the use of photocatalytic systems in hospital setting, focusing on products based on TiO.

METHODS

Specific keywords combinations were analitically searched in PubMed and Scopus databases.

RESULTS

Starting 80s-90s, over 2000 papers report "in vitro" studies on antimicrobial activity of TiO2 photocatalysis on several microorganisms including bacteria, viruses, fungi, yeasts, and antibiotic resistant strains. Besides, at least 4 selected papers addressed the potentials of this approach by "in field" studies, showing a widespread pool of applications in hospital and healthcare settings. However, the low number of available experiences and their heterogeneity represent major limitations to achieve a comprehensive final overview on effectiveness and feasibility of these technologies.

CONCLUSIONS

Photocatalytic systems based on TiO2 represent a promising strategy for hospital hygiene and HAI prevention. Additional "in field" studies are desirable in a next future to further evaluate and exploit this novel and interesting health technology.

摘要

背景

最近，人们考虑了几种先进技术来降低医院环境中的微生物负荷并控制医疗相关感染（HAIs）的发生率。预防HAIs的新策略不断发展，包括通过新型液体杀菌剂或非接触技术加强卫生程序，使用重金属或光活化光敏剂（如二氧化钛（TiO2）纳米颗粒）涂层的自消毒表面。

研究设计

回顾有关医院环境中光催化系统应用的出版物，重点关注基于TiO的产品。

方法

在PubMed和Scopus数据库中对特定关键词组合进行分析检索。

结果

从80年代到90年代开始，超过2000篇论文报道了关于TiO2光催化对包括细菌、病毒、真菌、酵母和抗生素耐药菌株在内的多种微生物抗菌活性的“体外”研究。此外，至少4篇选定的论文通过“实地”研究探讨了这种方法的潜力，表明其在医院和医疗环境中有广泛的应用。然而，可用经验数量较少及其异质性是全面最终概述这些技术的有效性和可行性的主要限制。