一种温和条件下使用重氮戊环酮的铜（I）催化茚满酮衍生物的简便同偶联反应。

A facile copper(i)-catalyzed homo-coupling of indanone derivatives using diaziridinone under mild conditions.

机构信息

Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA.

出版信息

Org Biomol Chem. 2019 Jul 24;17(29):6998-7001. doi: 10.1039/c9ob00901a.

Abstract

A novel and efficient Cu(i)-catalyzed homo-coupling of indanone derivatives using diaziridinone as an oxidant is described. A variety of 1,4-dicarbonyl compounds bearing two adjacent quaternary stereocenters were obtained in high yields with high diastereoselectivities via a base-free and operationally simple process under mild reaction conditions.

摘要

本文描述了一种新型、高效的吲哚酮衍生物的铜（I）催化同偶联反应，使用重氮戊环作为氧化剂。在温和的反应条件下，通过无碱和操作简单的过程，以高收率和高非对映选择性得到了多种含有两个相邻季立体中心的 1,4-二羰基化合物。