Zhu Yingguang, Xiong Tao, Han Wenyong, Shi Yian
Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States.
Org Lett. 2014 Dec 5;16(23):6144-7. doi: 10.1021/ol5030103. Epub 2014 Nov 24.
Transition-metal-catalyzed cross-coupling reactions are among the most powerful synthetic transformations. This paper describes an efficient copper-catalyzed homo- and cross-coupling of Grignard reagents with di-tert-butyldiaziridinone as oxidant under mild conditions, giving the coupling products in good to excellent yields. The reaction process has a broad substrate scope and is also effective for the C(sp)-C(sp(3)) coupling.
过渡金属催化的交叉偶联反应是最强大的合成转化反应之一。本文描述了一种在温和条件下,以二叔丁基二氮杂环丙烷酮为氧化剂,铜催化格氏试剂进行均偶联和交叉偶联的有效方法,偶联产物的产率良好至优异。该反应过程具有广泛的底物范围,对C(sp)-C(sp(3))偶联也有效。