使用重氮环丁酮的铜催化格氏试剂的氧化均偶联和交叉偶联反应。
Copper-catalyzed oxidative homo- and cross-coupling of Grignard reagents using diaziridinone.
作者信息
Zhu Yingguang, Xiong Tao, Han Wenyong, Shi Yian
机构信息
Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States.
出版信息
Org Lett. 2014 Dec 5;16(23):6144-7. doi: 10.1021/ol5030103. Epub 2014 Nov 24.
Transition-metal-catalyzed cross-coupling reactions are among the most powerful synthetic transformations. This paper describes an efficient copper-catalyzed homo- and cross-coupling of Grignard reagents with di-tert-butyldiaziridinone as oxidant under mild conditions, giving the coupling products in good to excellent yields. The reaction process has a broad substrate scope and is also effective for the C(sp)-C(sp(3)) coupling.
过渡金属催化的交叉偶联反应是最强大的合成转化反应之一。本文描述了一种在温和条件下，以二叔丁基二氮杂环丙烷酮为氧化剂，铜催化格氏试剂进行均偶联和交叉偶联的有效方法，偶联产物的产率良好至优异。该反应过程具有广泛的底物范围，对C(sp)-C(sp(3))偶联也有效。
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