[Cu(OH)(TMEDA)]₂Cl₂催化5-取代四唑与硼酸在温和条件下的区域选择性2-芳基化反应。

[Cu(OH)(TMEDA)]₂Cl₂-catalyzed regioselective 2-arylation of 5-substituted tetrazoles with boronic acids under mild conditions.

作者信息

Onaka Takuya, Umemoto Hideaki, Miki Yasuyoshi, Nakamura Akira, Maegawa Tomohiro

机构信息

Fujimoto Chemicals Co., Ltd. , 1-2-38, Kinrakuji-cho, Amagasaki, Hyogo 660-0806, Japan.

出版信息

J Org Chem. 2014 Jul 18;79(14):6703-7. doi: 10.1021/jo500862t. Epub 2014 Jul 7.

DOI:10.1021/jo500862t

PMID:24962401

Abstract

A mild and regioselective 2-arylation of 5-substituted tetrazoles is described. The reaction proceeds regioselectively with a variety of arylboronic acids in the presence of [Cu(OH)(TMEDA)]2Cl2 to afford 2,5-disubstituted tetrazoles. This is the first report of highly regioselective arylation of 5-alkyltetrazoles.

摘要

本文描述了一种温和且具有区域选择性的5-取代四唑的2-芳基化反应。该反应在[Cu(OH)(TMEDA)]2Cl2存在下，与多种芳基硼酸发生区域选择性反应，生成2,5-二取代四唑。这是关于5-烷基四唑高度区域选择性芳基化的首次报道。