Department of Ophthalmology, Philipps University of Marburg, Germany.
Research Synelixis Lab, Athens, Greece.
Cornea. 2019 Oct;38(10):1215-1221. doi: 10.1097/ICO.0000000000002035.
To present normative corneal densitometry (CD), thickness (CT), and volume (CV) after uneventful Descemet membrane endothelial keratoplasty (DMEK).
Medical records of 212 consecutive surgeries were reviewed. One hundred cases without intraoperative and postoperative complications were included (group 1). Scheimpflug CD of the optically relevant 0- to 2-mm zone and 2- to 6-mm annulus, CT at the 2-, 4-, and 6-mm rings, and CV at the 3-, 5-, and 7-mm zones were evaluated preoperatively and at 3, 6, 12, and 24 months postoperatively. The 24-month results were compared with an age-matched group of uncomplicated pseudophakic eyes (group 2; n = 20) and a group of healthy, young subjects (group 3; n = 30).
Total CD at 0 to 2 mm was 33.9 ± 10.7 grayscale units preoperatively and decreased to 20.3 ± 4.7 at 24 months (P < 0.001), being significantly higher compared with both control groups (P ≤ 0.026). Total CD at 2 to 6 mm was 27.9 ± 8.1 preoperatively and decreased to 20.2 ± 4.6 at 24 months (P < 0.001), showing no statistically significant difference compared with group 2 (P = 0.061). At 24 months, group 1 showed a similar central CT, CT at the 2-mm and 4-mm rings compared with group 2 (P ≥ 0.440); however, CT at 6 mm increased significantly (P = 0.008). CV at 3, 5, and 7 m decreased significantly at 24 months (P < 0.001), showing no significant differences compared with both control groups (P ≥ 0.122).
Twenty four months after uneventful DMEK, CT within the central 4-mm zone and CV at the 3-, 5-, and 7-mm zones were similar to uncomplicated pseudophakic eyes. The total CD at the 0- to 2-mm zone and midperipheral CT at the 6-mm ring were higher compared with the pseudophakic controls.
介绍无并发症的 Descemet 膜内皮角膜移植术（DMEK）后正常的角膜密度（CD）、厚度（CT）和体积（CV）。
回顾了 212 例连续手术的病历。纳入了 100 例无术中及术后并发症的病例（第 1 组）。评估了光学相关的 0-2mm 区和 2-6mm 环的 Scheimpflug CD、2、4 和 6mm 环的 CT 以及 3、5 和 7mm 区的 CV，分别在术前和术后 3、6、12 和 24 个月进行。将 24 个月的结果与无并发症的假性晶状体眼的年龄匹配组（第 2 组，n=20）和健康年轻受试者组（第 3 组，n=30）进行比较。
0-2mm 总 CD 术前为 33.9±10.7 灰度单位，术后 24 个月降至 20.3±4.7（P<0.001），与两组对照组相比均显著升高（P≤0.026）。2-6mm 总 CD 术前为 27.9±8.1，术后 24 个月降至 20.2±4.6（P<0.001），与第 2 组相比无统计学差异（P=0.061）。术后 24 个月，第 1 组与第 2 组相比，中央 CT、2mm 和 4mm 环的 CT 相似（P≥0.440）；然而，6mm 处的 CT 显著增加（P=0.008）。术后 24 个月，3、5 和 7m 处的 CV 显著降低（P<0.001），与两组对照组相比无显著差异（P≥0.122）。
无并发症的 DMEK 术后 24 个月，中央 4mm 区的 CT 和 3、5 和 7mm 区的 CV 与无并发症的假性晶状体眼相似。0-2mm 区的总 CD 和 6mm 环的中周 CT 高于假性晶状体对照组。
