Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali, 3814, Bangladesh.
J Ethnopharmacol. 2019 Oct 28;243:112080. doi: 10.1016/j.jep.2019.112080. Epub 2019 Jul 12.
Fimbristylis miliacea (L.) Vahl (Cyperaceae) is a grass like herb usually grows as a weed in rice fields and is mainly distributed in tropical or sub-tropical countries of south and south-east Asia, central America, northern Australia and west Africa. The plant has been traditionally used to treat fever as a form of poultice.
The present study aimed to investigate antipyretic and anti-nociceptive effects of methanol extract of leaves of Fimbristylis miliacea in mice model.
Antipyretic effect of Fimbristylis miliacea was examined using Baker's yeast induced hyperthermia test. Anti-nociceptive effect was investigated using acetic acid induced writhing test, formalin induced hind paw licking test and hot plate test.
The extract at concentration of 400 mg/kg produced significant reduction in body temperature after 0.5 h of administration (4.12 °F, p ≤ 0.001) and continued to decrease (after 4 h, 5.92 °F, p ≤ 0.001). Extracts at 100 mg/kg and 200 mg/kg decreased the temperature by about 2.77 °F (from 99.47 °F to 96.7 °F) and 5.58 °F (98.2 °F-92.62 °F) respectively after 4 h whereas paracetamol dropped by about 7.2 °F (p ≤ 0.001). The extract showed significant decrease in number of writhes at all concentrations. Highest effect was found at 200 mg/kg having 35.7 writhes (p ≤ 0.001), much lower than control (89.2); standard drug diclofenac showed 23.2 writhes. Percent inhibition of writhing were 54.26 and 73.99 for 200 mg/kg and diclofenac respectively. The result of hind paw licking test also corroborated writhing test. Significant reduction in percent inhibition of licking was observed mainly in late phase. Percent inhibition of licking were 93.77 and 51.55 for 400 mg/kg extract and diclofenac respectively. In hot plate test, extract at 400 mg/kg showed significant increase in latency from 10.77 s to 13.59 s (p ≤ 0.05). Extract at this dose after 2 h demonstrated greater percent maximal effect (43.26%) compared to ketorolac (40.19%).
The experiment confirmed the traditional use of F. miliacea in the treatment of fever with possible anti-nociceptive effects.
米草（Cyperaceae）是一种类似草的草本植物，通常作为稻田中的杂草生长，主要分布在南亚和东南亚、中美洲、澳大利亚北部和西非的热带或亚热带国家。该植物传统上被用于治疗发热，作为一种敷布形式。
本研究旨在研究米草叶甲醇提取物在小鼠模型中的解热和抗伤害作用。
使用贝克氏酵母诱导的发热试验研究米草的解热作用。采用醋酸诱导扭体试验、福尔马林诱导后爪舔舐试验和热板试验研究抗伤害作用。
提取物在 400mg/kg 浓度下给药 0.5 小时后显著降低体温（4.12°F，p≤0.001），并持续降低（4 小时后，5.92°F，p≤0.001）。100mg/kg 和 200mg/kg 的提取物分别使体温降低约 2.77°F（从 99.47°F 降至 96.7°F）和 5.58°F（98.2°F-92.62°F），而扑热息痛降低约 7.2°F（p≤0.001）。提取物在所有浓度下均显著减少扭体次数。在 200mg/kg 时效果最高，扭体 35.7 次（p≤0.001），远低于对照（89.2）；标准药物双氯芬酸显示 23.2 次扭体。200mg/kg 和双氯芬酸的扭体抑制率分别为 54.26%和 73.99%。后爪舔舐试验的结果也与扭体试验相符。主要在后期观察到舔舐抑制百分率的显著降低。400mg/kg 提取物和双氯芬酸的舔舐抑制百分率分别为 93.77%和 51.55%。在热板试验中，400mg/kg 提取物使潜伏期从 10.77s 增加到 13.59s（p≤0.05）。与酮咯酸（40.19%）相比，该剂量的提取物在 2 小时后表现出更大的最大效应百分比（43.26%）。
该实验证实了米草传统上用于治疗发热的用途，可能具有抗伤害作用。
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