头围较小且受教育程度较低预示着更高的痴呆症发病风险：上海老龄化研究。
Smaller Head Circumference Combined with Lower Education Predicts High Risk of Incident Dementia: The Shanghai Aging Study.
机构信息
Department of Biostatistics, School of Public Health, Fudan University, Shanghai, China.
Department of Epidemiology and Biostatistics, University of South Florida, Tampa, Florida, USA.
出版信息
Neuroepidemiology. 2019;53(3-4):152-161. doi: 10.1159/000501103. Epub 2019 Jul 15.
INTRODUCTION
An important index of brain reserve is the maximal attained brain size, which can be estimated by measuring the head circumference (HC). We investigated the association of HC and education with incident dementia in a population-based study of Chinese older adults.
METHODS
We conducted a prospective follow-up study of 1,659 non-demented participants with a mean age of 71.5 years. Characteristics and anthropometry of the participants were collected at baseline. Consensus diagnoses for dementia were made using DSM-IV criteria based on functional, neurological, and neuropsychological assessments.
RESULTS
We identified 168 new-onset dementia cases after a mean of 5.2 years of follow-up. Participants with smaller HC combined with low educational attainment had a significantly higher risk of incident dementia than those with larger HC who had completed more than 12 years of education (adjusted hazard ratio 4.48, 95% CI 2.47-8.12).
DISCUSSION/CONCLUSION: Our results suggest that smaller HC in combination with low education leads to a markedly increased risk of dementia.
简介
大脑储备的一个重要指标是最大脑容量，可通过测量头围（HC）来估计。我们在一项针对中国老年人的基于人群的研究中，调查了 HC 和教育与痴呆发病的相关性。
方法
我们对 1659 名无痴呆的参与者进行了前瞻性随访研究，平均年龄为 71.5 岁。基线时收集参与者的特征和人体测量数据。根据功能、神经和神经心理学评估，使用 DSM-IV 标准进行共识诊断。
结果
在平均 5.2 年的随访后，我们发现 168 例新发痴呆病例。与完成 12 年以上教育的 HC 较大且受教育程度较高的参与者相比，HC 较小且受教育程度较低的参与者发生痴呆的风险明显更高（调整后的危险比 4.48，95%CI 2.47-8.12）。
讨论/结论：我们的结果表明，较小的 HC 加上较低的教育水平会显著增加痴呆的风险。
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