[使用γ-羟基丁酸钠、维生素E和谷胱甘肽预防复苏后心肌能量代谢障碍]
[Prevention of post-resuscitation impairment of energy metabolism in the myocardium using sodium gamma-hydroxybutyrate, ionol and gutimine].
作者信息
Dolgikh V T
出版信息
Vopr Med Khim. 1988 Jan-Feb;34(1):33-8.
Long-term impairments of energy metabolisms in myocardium were found in rats after clinical death caused by acute hemorrhage. Bioenergetics of myocardium tended to normalize within a month after resuscitation. Severity of postresuscitation period correlated with the level of deteriorations observed in energy metabolism. Preadministration of gamma-aminobutyric acid, ionol and gutimine decreased these impairments as well as the postresuscitation lethality. Considering the final results of resuscitation the efficiency of the drugs studied might be arranged in a following order: gamma-aminobutyric acid, ionol, gutimine.
在急性出血导致临床死亡后的大鼠中，发现心肌能量代谢存在长期损伤。复苏后一个月内心肌生物能量学趋于正常。复苏后期的严重程度与能量代谢中观察到的恶化程度相关。预先给予γ-氨基丁酸、离子醇和古替明可减轻这些损伤以及复苏后的致死率。考虑到复苏的最终结果，所研究药物的有效性可能按以下顺序排列：γ-氨基丁酸、离子醇、古替明。
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