Meerson F Z, Dolgikh V T
Biull Eksp Biol Med. 1983 Apr;95(4):13-6.
Clinical death of animals caused by acute hemorrhage and subsequent resuscitation induce lipid peroxidation in the myocardium accompanied by depression of contractile function and massive efflux of enzymes into the coronary perfusate. Preliminary administration of the antioxidant ionol (100 mg/kg) for 3 days prior to clinical death resulted in a twofold decrease of the lethality during the post-resuscitation period, substantially diminishing activation of lipid peroxidation and efflux of enzymes to the coronary perfusate. Disturbances of myocardial contractility were thus prevented to a considerable degree.
急性出血导致动物临床死亡并随后进行复苏，会引发心肌脂质过氧化，同时伴有收缩功能下降以及大量酶释放入冠状动脉灌注液中。在临床死亡前3天预先给予抗氧化剂离子醇（100毫克/千克），可使复苏后期间的致死率降低两倍，显著减少脂质过氧化的激活以及酶向冠状动脉灌注液中的释放。从而在很大程度上防止了心肌收缩性的紊乱。
