接受癌症治疗儿童的症状生物标志物：科学现状
Symptom Biomarkers for Children Receiving Treatment for Cancer: State of the Science.
作者信息
Mandrell Belinda N, Withycombe Janice S
机构信息
1 St. Jude Children's Research Hospital, Memphis, TN, USA.
2 Emory University, Atlanta, GA, USA.
出版信息
J Pediatr Oncol Nurs. 2019 Jul/Aug;36(4):280-286. doi: 10.1177/1043454219859233.
The Children's Oncology Group Nursing Discipline has identified the most concerning symptoms during childhood cancer treatment and the need for continued symptom assessment and intervention during treatment trajectory. To develop appropriate interventions, symptom science strategies must explore the biological mechanisms associated with symptoms of cancer and cancer treatment. To explore the associated biological mechanisms, biomarkers have been recommended for inclusion in symptom science studies, when applicable. The biomarker assessed, as well as the method of collection and storage, can affect the reliability and validity of the study results and clinical implication. This review will describe biomarkers that have been described in pediatric oncology symptom science research and provides special considerations for specimen collection and processing.
儿童肿瘤学组护理学科已经确定了儿童癌症治疗期间最令人担忧的症状，以及在治疗过程中持续进行症状评估和干预的必要性。为了制定适当的干预措施，症状科学策略必须探索与癌症及癌症治疗症状相关的生物学机制。为了探索相关的生物学机制，建议在适用时将生物标志物纳入症状科学研究。所评估的生物标志物以及采集和储存方法会影响研究结果的可靠性和有效性以及临床意义。本综述将描述儿科肿瘤症状科学研究中已提及的生物标志物，并对样本采集和处理提供特殊注意事项。
Zotero 插件