肺及非肺手术后间质性肺炎的术后急性加重：一项回顾性研究。
Postoperative acute exacerbation of interstitial pneumonia in pulmonary and non-pulmonary surgery: a retrospective study.
机构信息
Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
出版信息
Respir Res. 2019 Jul 15;20(1):154. doi: 10.1186/s12931-019-1128-5.
BACKGROUND
Acute exacerbation of interstitial pneumonia (AE-IP) is a serious complication of pulmonary surgery in patients with IP. However, little is known about AE-IP after non-pulmonary surgery. The aim of this study was to determine the frequency of AE-IP after non-pulmonary surgery and identify its risk factors.
METHODS
One hundred and fifty-one patients with IP who underwent pulmonary surgery and 291 who underwent non-pulmonary surgery were retrospectively investigated.
RESULTS
AE-IP developed in 5 (3.3%) of the 151 patients in the pulmonary surgery group and 4 (1.4%) of the 291 in the non-pulmonary surgery group; the difference was not statistically significant. A logistic regression model showed that serum C-reactive protein (CRP) was a predictor of AE-IP in the non-pulmonary surgery group (odds ratio 1.187, 95% confidence interval 1.073-1.344, P = 0.002).
CONCLUSIONS
This is the first study to compare the frequency of AE-IP after pulmonary surgery with that after non-pulmonary surgery performed under the same conditions. The results suggest that the frequency of AE-IP after non-pulmonary surgery is similar to that after pulmonary surgery. A high preoperative C-reactive protein level is a potential risk factor for AE-IP after non-pulmonary surgery.
背景
间质性肺炎（IP）急性加重是 IP 患者肺部手术后的严重并发症。然而，对于非肺部手术后的 IP 急性加重（AE-IP）知之甚少。本研究旨在确定非肺部手术后 AE-IP 的发生率，并确定其危险因素。
方法
回顾性调查了 151 例接受肺部手术和 291 例接受非肺部手术的 IP 患者。
结果
肺部手术组 5 例（3.3%）和非肺部手术组 4 例（1.4%）发生 AE-IP；差异无统计学意义。Logistic 回归模型显示，血清 C 反应蛋白（CRP）是非肺部手术组 AE-IP 的预测因子（比值比 1.187，95%置信区间 1.073-1.344，P=0.002）。
结论
这是第一项比较相同条件下肺部手术后和非肺部手术后 AE-IP 发生率的研究。结果表明，非肺部手术后 AE-IP 的发生率与肺部手术后相似。术前高 C 反应蛋白水平是非肺部手术后 AE-IP 的潜在危险因素。
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