肝 X 受体激动剂抑制原代人成纤维细胞中的基孔肯雅病毒复制。
Inhibition of Chikungunya Virus Replication in Primary Human Fibroblasts by Liver X Receptor Agonist.
机构信息
Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
出版信息
Antimicrob Agents Chemother. 2019 Aug 23;63(9). doi: 10.1128/AAC.01220-19. Print 2019 Sep.
Abstract
The mosquito-borne chikungunya virus (CHIKV) causes acute pain and joint inflammation, and in recent years the virus has caused large epidemics in previously CHIKV-free geographic areas. To advance the understanding of host factors that antagonize CHIKV, we show that synthetic agonist of liver X receptor (LXR-623) inhibits CHIKV replication by upregulating the cholesterol exporter ABCA1 and that endogenous and pharmacological activation of interferon signaling pathway partners with LXR-623 to generate a superior antiviral state.
摘要
虫媒传播的基孔肯雅病毒（CHIKV）可引起急性疼痛和关节炎症，近年来，该病毒已在以前无 CHIKV 的地理区域引发了大规模疫情。为了深入了解拮抗 CHIKV 的宿主因素，我们发现合成肝 X 受体（LXR-623）激动剂可通过上调胆固醇外排蛋白 ABCA1 抑制 CHIKV 复制，内源性和药理学激活干扰素信号通路与 LXR-623 协同作用可产生更优的抗病毒状态。
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