Association of sirolimus with pericardial effusion in renal transplant patient and discussion of potential mechanism.
作者信息
Meng Lingbin, Deng Bo, Liu Baoqiong, Gordon Dwayne
机构信息
Internal Medicine, Florida Hospital/AdventHealth, Orlando, Florida, USA.
出版信息
BMJ Case Rep. 2019 Jul 15;12(7):e230269. doi: 10.1136/bcr-2019-230269.
Abstract
Sirolimus is an important immunosuppressive drug in renal transplantation but contains numerous side effects. In this study, we describe a case of renal transplant recipient treated with sirolimus who developed pericardial effusion associated with interstitial pneumonia. An extensive search for alternative causes were all negative, and all symptoms disappeared after sirolimus interruption. Therefore, this case demonstrates that sirolimus can cause pericardial effusion possibly through a proinflammatory mechanism.
摘要
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