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他克莫司作为肾移植受者心包积液的罕见病因。

Tacrolimus as a Rare Cause of Pericardial Effusion in a Renal Transplant Recipient.

作者信息

Prashar Rohini, Stewart Diana, Moza Ankush

机构信息

Division of Nephrology and Transplant Institute, Henry Ford Hospital, Detroit, MI 48202, USA.

University of Toledo Medical Center, Ohio, USA.

出版信息

Heart Views. 2017 Oct-Dec;18(4):145-148. doi: 10.4103/HEARTVIEWS.HEARTVIEWS_6_17.

DOI:10.4103/HEARTVIEWS.HEARTVIEWS_6_17
PMID:29326779
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5755197/
Abstract

Pericardial effusion in a renal transplant recipient represents a diagnostic conundrum with a variety of differential diagnoses. Immunosuppressive medications such as sirolimus have been linked to pericardial effusions in the reported literature. Tacrolimus has been reported to be associated with pleural effusions and ascites. We present a case of a patient with tacrolimus as the likely cause of a recurrent pericardial effusion.

摘要

肾移植受者出现心包积液是一个诊断难题，存在多种鉴别诊断。在已发表的文献中，免疫抑制药物如西罗莫司与心包积液有关。据报道，他克莫司与胸腔积液和腹水有关。我们报告一例患者，他克莫司可能是复发性心包积液的病因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f8d/5755197/f6f58ef5d4dd/HV-18-145-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f8d/5755197/e2e2c51bee95/HV-18-145-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f8d/5755197/f6f58ef5d4dd/HV-18-145-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f8d/5755197/e2e2c51bee95/HV-18-145-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f8d/5755197/f6f58ef5d4dd/HV-18-145-g002.jpg

相似文献

1
Tacrolimus as a Rare Cause of Pericardial Effusion in a Renal Transplant Recipient.他克莫司作为肾移植受者心包积液的罕见病因。
Heart Views. 2017 Oct-Dec;18(4):145-148. doi: 10.4103/HEARTVIEWS.HEARTVIEWS_6_17.
2
Pericardial Effusion Associated With Sirolimus Use After Renal Transplantation: A Single-Center Case Series.肾移植后使用西罗莫司相关的心包积液：一项单中心病例系列研究
Transplant Proc. 2019 Jul-Aug;51(6):1739-1743. doi: 10.1016/j.transproceed.2019.04.043. Epub 2019 Jun 14.
3
Pleural and pericardial effusions combined with ascites in a patient with severe sunitinib-induced hypothyroidism.舒尼替尼引起严重甲状腺功能减退患者出现胸腔和心包积液合并腹水。
Acta Clin Belg. 2016 Jun;71(3):175-7. doi: 10.1179/2295333715Y.0000000065. Epub 2016 Feb 7.
4
Massive pleural effusion in a renal transplant recipient on tacrolimus.一名接受他克莫司治疗的肾移植受者出现大量胸腔积液。
Indian J Nephrol. 2014 Sep;24(5):318-20. doi: 10.4103/0971-4065.133024.
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Pericardial effusion coincident with sirolimus therapy: a review of Wyeth's safety database.
Transplantation. 2008 Feb 27;85(4):645-7. doi: 10.1097/TP.0b013e3181636061.
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Ascites, pleural, and pericardial effusions in acute pancreatitis. A prospective study of incidence, natural history, and prognostic role.急性胰腺炎中的腹水、胸腔积液和心包积液。发病率、自然病程及预后作用的前瞻性研究。
Dig Dis Sci. 1996 May;41(5):848-52. doi: 10.1007/BF02091521.
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A case of Meigs' syndrome with preceding pericardial effusion in advance of pleural effusion.1例梅格斯综合征，心包积液先于胸腔积液出现。
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Association between parapneumonic effusion and pericardial effusion in a pediatric cohort.儿科队列中肺炎旁胸腔积液与心包积液的关联。
Pediatrics. 2008 Dec;122(6):e1231-5. doi: 10.1542/peds.2008-0171. Epub 2008 Nov 4.
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Diagnostic value of chest radiography for pericardial effusion.胸部X线摄影对心包积液的诊断价值。
J Am Coll Cardiol. 1993 Aug;22(2):588-93. doi: 10.1016/0735-1097(93)90069-d.
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Video-assisted thoracoscopic pericardial fenestration for loculated or recurrent effusions.电视辅助胸腔镜下心包开窗术治疗包裹性或复发性积液。
Eur J Cardiothorac Surg. 1998 Oct;14(4):403-8. doi: 10.1016/s1010-7940(98)00153-5.

引用本文的文献

1
Right Heart Failure With Recurrent Pericardial Effusion Mimicking Effusive-Constrictive Pericarditis Several Years After Renal Transplantation.右心衰竭伴复发性心包积液，酷似肾移植后数年发生的心包渗出-缩窄性。
J Investig Med High Impact Case Rep. 2022 Jan-Dec;10:23247096221111765. doi: 10.1177/23247096221111765.
2
Association of sirolimus with pericardial effusion in renal transplant patient and discussion of potential mechanism.肾移植患者中雷帕霉素与心包积液的关联及潜在机制探讨
BMJ Case Rep. 2019 Jul 15;12(7):e230269. doi: 10.1136/bcr-2019-230269.
3
Tacrolimus-induced Ascites after Liver Transplant.

本文引用的文献

1
Massive pleural effusion in a renal transplant recipient on tacrolimus.一名接受他克莫司治疗的肾移植受者出现大量胸腔积液。
Indian J Nephrol. 2014 Sep;24(5):318-20. doi: 10.4103/0971-4065.133024.
2
Post-transplant recurrent pericarditis with pericardial tamponade is successfully treated with colchicine: A case report.秋水仙碱成功治疗移植后复发性心包炎伴心包填塞：一例报告
Exp Ther Med. 2014 Sep;8(3):801-804. doi: 10.3892/etm.2014.1824. Epub 2014 Jul 4.
3
Focus on mTOR inhibitors and tacrolimus in renal transplantation: pharmacokinetics, exposure-response relationships, and clinical outcomes.
肝移植后他克莫司诱发的腹水
Int J Organ Transplant Med. 2018;9(2):102-104. Epub 2018 May 1.
关注肾移植中的mTOR抑制剂和他克莫司：药代动力学、暴露-反应关系及临床结局。
Transpl Immunol. 2014 Jun;31(1):22-32. doi: 10.1016/j.trim.2014.05.002. Epub 2014 May 24.
4
Sirolimus therapy may cause cardiac tamponade.西罗莫司治疗可能导致心脏压塞。
Transpl Int. 2013 Feb;26(2):e4-7. doi: 10.1111/tri.12025. Epub 2012 Nov 29.
5
Tacrolimus. An update of its pharmacology and clinical efficacy in the management of organ transplantation.他克莫司。其在器官移植管理中的药理学及临床疗效的最新进展。
Drugs. 1997 Dec;54(6):925-75. doi: 10.2165/00003495-199754060-00009.
6
Randomised trial comparing tacrolimus (FK506) and cyclosporin in prevention of liver allograft rejection. European FK506 Multicentre Liver Study Group.比较他克莫司（FK506）和环孢素预防肝移植排斥反应的随机试验。欧洲FK506多中心肝脏研究组。
Lancet. 1994 Aug 13;344(8920):423-8.
7
Pericarditis following renal transplantation.肾移植后心包炎
Transplantation. 1991 Jun;51(6):1229-32. doi: 10.1097/00007890-199106000-00016.