Service de Transplantation Rénale et Soins Intensifs, Hôpital Necker, Assistance Publique Hôpitaux de Paris, Université Paris Descartes, Paris, France.
Transpl Int. 2013 Feb;26(2):e4-7. doi: 10.1111/tri.12025. Epub 2012 Nov 29.
The side-effects associated with the immunosuppressive drug sirolimus are numerous and constitute a major limitation for its use in renal transplantation. In this study, we describe two cases of renal transplant recipients treated with sirolimus who developed pericardial tamponade associated with interstitial pneumonia, proteinuria, microcytic anemia and, in one case, lymphocytic meningitidis. An extensive search for infectious agents was negative, and all symptoms disappeared after sirolimus interruption. Therefore, this case demonstrates for the first time that sirolimus can cause pericardial tamponade as well as lymphocytic meningitidis.
与免疫抑制剂西罗莫司相关的副作用很多，这极大地限制了其在肾移植中的应用。本研究描述了两例肾移植受者应用西罗莫司后发生心包填塞伴间质性肺炎、蛋白尿、小细胞性贫血的病例，其中一例还合并淋巴细胞性脑膜炎。虽然进行了广泛的感染性病因筛查，但均为阴性，且所有症状在停用西罗莫司后均消失。因此，本病例首次证实西罗莫司可导致心包填塞和淋巴细胞性脑膜炎。
