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双颞叶电休克治疗成功缓解难治性分裂情感障碍患者的显著躯体妄想

Successful Resolution of Prominent Somatic Delusions Following Bi-temporal Electroconvulsive Therapy in a patient with Treatment-Resistant Schizoaffective Disorder.

作者信息

Cohen Joshua L, Vu My-Hanh Thi, Beg Mirza Adam, Sivaraman Soumya, Birur Badari

机构信息

Cohen, PhD, School of Medicine, University of Alabama at Birmingham. Thi Vu, MD, PGY3 Resident, Department of Psychiatry, University of Alabama at Birmingham. Adam Beg, BS, School of Medicine, University of Alabama at Birmingham. Sivaraman, MD, Assistant Professor, Department of Psychiatry, University of Alabama at Birmingham. Birur, MD, Associate Professor, Department of Psychiatry, University of Alabama at Birmingham.

出版信息

Psychopharmacol Bull. 2019 Jun 20;49(2):52-56.

Abstract

Somatic delusions occur in a variety of psychiatric disorders including schizophrenia, major depressive disorder, and bipolar disorder. Somatization is associated with lower quality of life and greater risk for suicide. Treatment of somatic delusions is extremely challenging. Here we report an interesting case of severe somatic delusions in a 48-year-old African-American female with a long history of treatment resistant schizoaffective disorder, with multiple somatic complaints surrounding constipation, pregnancy, jaw pain, body aches, vaginal itch, malodorous urine, and neck pain, despite normal clinical examinations and negative medical work up. Additionally, she endorsed persistent auditory and visual hallucinations. Her symptoms remained resistant to several trials of psychotropic medications, including clozapine. Chart review of past hospitalizations revealed significant improvement with Electroconvulsive Therapy (ECT), so the team decided to perform a course of six bi-temporal ECT treatments administered over two weeks. Stimulation was applied at a current of 800 mA for 4.5s, with a pulse width of 1 ms and frequency of 60 Hz. This case illustrates the successful use of ECT in treating prominent somatic delusions in a patient with treatment-resistant schizoaffective disorder.

摘要

躯体妄想发生于多种精神疾病,包括精神分裂症、重度抑郁症和双相情感障碍。躯体化与生活质量降低及自杀风险增加有关。躯体妄想的治疗极具挑战性。在此,我们报告一例有趣的病例,一名48岁非裔美国女性患有长期难治性分裂情感障碍,存在严重的躯体妄想,尽管临床检查正常且医学检查结果为阴性,但仍有围绕便秘、怀孕、颌部疼痛、身体疼痛、阴道瘙痒、尿液异味及颈部疼痛的多种躯体不适主诉。此外,她还存在持续性听觉和视觉幻觉。她的症状对包括氯氮平在内的多种精神药物试验均有抵抗。对其既往住院病历的回顾显示,电休克治疗(ECT)有显著改善,因此该团队决定进行为期两周的六个双侧颞部ECT治疗疗程。以800 mA的电流进行刺激,持续4.5秒,脉冲宽度为1毫秒,频率为60赫兹。该病例说明了ECT在治疗难治性分裂情感障碍患者突出的躯体妄想方面的成功应用。

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Treatment resistant somatic delusions in bipolar disorder.双相情感障碍中对治疗耐药的躯体妄想
BMJ Case Rep. 2015 Jul 7;2015:bcr2014208375. doi: 10.1136/bcr-2014-208375.
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Electroconvulsive therapy for schizophrenia.精神分裂症的电休克治疗
Cochrane Database Syst Rev. 2005 Apr 18(2):CD000076. doi: 10.1002/14651858.CD000076.pub2.

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