• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

脓毒症和脓毒性休克治疗方法的当前证据评估

A current appraisal of evidence for the approach to sepsis and septic shock.

作者信息

Varon Jack, Baron Rebecca M

机构信息

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis St, Boston, MA 02115, USA.

出版信息

Ther Adv Infect Dis. 2019 Jul 5;6:2049936119856517. doi: 10.1177/2049936119856517. eCollection 2019 Jan-Dec.

DOI:10.1177/2049936119856517
PMID:31308945
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6613063/
Abstract

Sepsis is a life-threatening syndrome of a dysregulated host response to infection. Despite advances in diagnosis and treatment, sepsis remains a significant cause of morbidity and mortality. Many aspects of the diagnosis and clinical management of sepsis require further study and remain controversial. This review aims to summarize relevant literature and controversies regarding the evaluation and management of sepsis and septic shock.

摘要

脓毒症是宿主对感染反应失调的一种危及生命的综合征。尽管在诊断和治疗方面取得了进展,但脓毒症仍然是发病和死亡的重要原因。脓毒症的诊断和临床管理的许多方面需要进一步研究,并且仍然存在争议。本综述旨在总结关于脓毒症和脓毒性休克评估与管理的相关文献及争议。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b794/6613063/4860ea32e508/10.1177_2049936119856517-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b794/6613063/4860ea32e508/10.1177_2049936119856517-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b794/6613063/4860ea32e508/10.1177_2049936119856517-fig1.jpg

相似文献

1
A current appraisal of evidence for the approach to sepsis and septic shock.脓毒症和脓毒性休克治疗方法的当前证据评估
Ther Adv Infect Dis. 2019 Jul 5;6:2049936119856517. doi: 10.1177/2049936119856517. eCollection 2019 Jan-Dec.
2
Sepsis Care Pathway 2019.2019年脓毒症护理路径
Qatar Med J. 2019 Nov 7;2019(2):4. doi: 10.5339/qmj.2019.qccc.4. eCollection 2019.
3
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).《脓毒症及脓毒性休克第三次国际共识定义(脓毒症-3)》
JAMA. 2016 Feb 23;315(8):801-10. doi: 10.1001/jama.2016.0287.
4
Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012.拯救脓毒症运动:严重脓毒症和脓毒性休克管理国际指南:2012 年。
Crit Care Med. 2013 Feb;41(2):580-637. doi: 10.1097/CCM.0b013e31827e83af.
5
A new definition of sepsis (Sepsis-3) - aims, advantages, and controversies.脓毒症的新定义(脓毒症-3)——目标、优势及争议
Epidemiol Mikrobiol Imunol. 2018 Spring;67(1):36-43.
6
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012.拯救脓毒症运动:严重脓毒症和脓毒性休克管理国际指南,2012 年。
Intensive Care Med. 2013 Feb;39(2):165-228. doi: 10.1007/s00134-012-2769-8. Epub 2013 Jan 30.
7
Association of Sex Differences with Mortality and Organ Dysfunction in Patients with Sepsis and Septic Shock.脓毒症和脓毒性休克患者性别差异与死亡率及器官功能障碍的关联
J Pers Med. 2023 May 15;13(5):836. doi: 10.3390/jpm13050836.
8
Bacterial Sepsis细菌性脓毒症
9
The use of steroids in the treatment of severe sepsis and septic shock.在严重脓毒症和感染性休克的治疗中使用类固醇。
Best Pract Res Clin Endocrinol Metab. 2011 Oct;25(5):735-43. doi: 10.1016/j.beem.2011.05.006.
10
Society for Maternal-Fetal Medicine Consult Series #67: Maternal sepsis.母胎医学会咨询系列第 67 号:母体脓毒症。
Am J Obstet Gynecol. 2023 Sep;229(3):B2-B19. doi: 10.1016/j.ajog.2023.05.019. Epub 2023 May 24.

引用本文的文献

1
Impact of early haemodynamic assessment by echocardiography on organ dysfunction and outcome of patients admitted to the emergency department with sepsis or septic shock: protocol of a multicentre randomised controlled trial (GENESIS).超声心动图早期血流动力学评估对因脓毒症或脓毒性休克入住急诊科患者器官功能障碍及预后的影响:一项多中心随机对照试验(GENESIS)方案
BMJ Open. 2025 May 6;15(5):e098304. doi: 10.1136/bmjopen-2024-098304.
2
Association Between Variants of the Mannose-Binding Lectin 2 Gene and Susceptibility to Sepsis in the Hainan Island.海南岛人群甘露聚糖结合凝集素 2 基因多态性与脓毒症易感性的关联
Med Sci Monit. 2022 Jun 8;28:e936134. doi: 10.12659/MSM.936134.
3

本文引用的文献

1
The Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis (CLOVERS) randomized clinical trial.脓毒症晶体液大量输注或血管加压药早期复苏(CLOVERS)随机临床试验
Intern Emerg Med. 2023 Nov;18(8):2419-2421. doi: 10.1007/s11739-023-03419-0. Epub 2023 Sep 11.
2
Inhibitors of the PilF ATPase provoke type IV pilus disassembly.PilF ATP 酶抑制剂会引发 IV 型菌毛解体。
Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8481-8486. doi: 10.1073/pnas.1817757116. Epub 2019 Apr 4.
3
Development of a novel short 12-meric papiliocin-derived peptide that is effective against Gram-negative sepsis.
Surfactant Protein D Influences Mortality During Abdominal Sepsis by Facilitating Colonization in the Gut.
表面活性蛋白D通过促进肠道定植影响腹部脓毒症期间的死亡率。
Crit Care Explor. 2022 May 18;4(5):e0699. doi: 10.1097/CCE.0000000000000699. eCollection 2022 May.
4
Comparison of 5% human albumin and normal saline for fluid resuscitation in sepsis induced hypotension among patients with cirrhosis (FRISC study): a randomized controlled trial.肝硬化伴脓毒症性低血压患者中 5%人血白蛋白与生理盐水用于液体复苏的比较(FRISC 研究):一项随机对照试验。
Hepatol Int. 2021 Aug;15(4):983-994. doi: 10.1007/s12072-021-10164-z. Epub 2021 May 25.
5
Update on diagnosis and management of sepsis in cirrhosis: Current advances.肝硬化患者脓毒症的诊断与管理进展:当前研究进展
World J Hepatol. 2020 Aug 27;12(8):451-474. doi: 10.4254/wjh.v12.i8.451.
开发一种新型的短 12 肽的乳链菌肽衍生肽,可有效对抗革兰氏阴性菌败血症。
Sci Rep. 2019 Mar 7;9(1):3817. doi: 10.1038/s41598-019-40577-8.
4
Sepsis Surveillance Using Adult Sepsis Events Simplified eSOFA Criteria Versus Sepsis-3 Sequential Organ Failure Assessment Criteria.使用成人脓毒症事件简化 eSOFA 标准与脓毒症 3 序贯器官衰竭评估标准进行脓毒症监测。
Crit Care Med. 2019 Mar;47(3):307-314. doi: 10.1097/CCM.0000000000003521.
5
Effect and Safety of Meropenem-Vaborbactam versus Best-Available Therapy in Patients with Carbapenem-Resistant Enterobacteriaceae Infections: The TANGO II Randomized Clinical Trial.美罗培南-巴坦与最佳可用疗法治疗耐碳青霉烯类肠杆菌科细菌感染患者的疗效和安全性:TANGO II随机临床试验
Infect Dis Ther. 2018 Dec;7(4):439-455. doi: 10.1007/s40121-018-0214-1. Epub 2018 Oct 1.
6
Precision Immunotherapy for Sepsis.精准免疫疗法治疗败血症。
Front Immunol. 2018 Sep 5;9:1926. doi: 10.3389/fimmu.2018.01926. eCollection 2018.
7
Mortality Changes Associated with Mandated Public Reporting for Sepsis. The Results of the New York State Initiative.与脓毒症强制公共报告相关的死亡率变化。纽约州倡议的结果。
Am J Respir Crit Care Med. 2018 Dec 1;198(11):1406-1412. doi: 10.1164/rccm.201712-2545OC.
8
Trends in "usual care" for septic shock.感染性休克“常规治疗”的趋势。
Infect Control Hosp Epidemiol. 2018 Sep;39(9):1125-1126. doi: 10.1017/ice.2018.154. Epub 2018 Jul 19.
9
Adding a C-terminal Cysteine (CTC) Can Enhance the Bactericidal Activity of Three Different Antimicrobial Peptides.添加C末端半胱氨酸(CTC)可增强三种不同抗菌肽的杀菌活性。
Front Microbiol. 2018 Jun 28;9:1440. doi: 10.3389/fmicb.2018.01440. eCollection 2018.
10
Association of the Quick Sequential (Sepsis-Related) Organ Failure Assessment (qSOFA) Score With Excess Hospital Mortality in Adults With Suspected Infection in Low- and Middle-Income Countries.快速序贯器官衰竭评估(qSOFA)评分与中低收入国家疑似感染成人医院过度死亡率的关系。
JAMA. 2018 Jun 5;319(21):2202-2211. doi: 10.1001/jama.2018.6229.